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Mesoporous calcium magnesium silicate/polylactic acid composite material as well as preparation method and use thereof

A technology of mesoporous calcium magnesium silicate and composite materials, which is applied in the field of mesoporous calcium magnesium silicate/polylactic acid composite materials and its preparation and application, can solve the problem that bone repair materials are difficult to have both biodegradable osseointegration effects and mechanical Performance and other issues, to achieve good biocompatibility and degradation performance, moderate mechanical properties

Inactive Publication Date: 2014-10-08
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defect that bone repair materials in the prior art are difficult to have good biodegradability, good osseointegration effect and mechanical properties, and to provide a mesoporous calcium magnesium silicate / polylactic acid composite Materials and their preparation methods and applications

Method used

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  • Mesoporous calcium magnesium silicate/polylactic acid composite material as well as preparation method and use thereof
  • Mesoporous calcium magnesium silicate/polylactic acid composite material as well as preparation method and use thereof
  • Mesoporous calcium magnesium silicate/polylactic acid composite material as well as preparation method and use thereof

Examples

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Embodiment 1

[0029] A method for preparing a mesoporous calcium magnesium silicate / polylactic acid composite material, comprising the steps of: drying 90 parts by weight of L-polylactic acid and 10 parts by weight of mesoporous calcium magnesium silicate at 90°C for 6 hours , mixed evenly in a high-speed mixer, melt-blended with an open mill, and formed, and then ready; wherein, the opening temperature is 180° C., and the opening time is 15 minutes.

Embodiment 2

[0031] A method for preparing a mesoporous calcium magnesium silicate / polylactic acid composite material, comprising the following steps: drying 80 parts by weight of D-polylactic acid and 20 parts by weight of mesoporous calcium magnesium silicate at 120°C for 6 hours , mixed evenly in a high-speed mixer, melted and blended with an internal mixer, and formed; wherein, the internal mixer temperature is 180°C, the internal mixer time is 10 minutes, and the internal mixer speed is 60rpm.

Embodiment 3

[0033] A method for preparing a mesoporous calcium magnesium silicate / polylactic acid composite material, comprising the steps of: drying 70 parts by weight of L-polylactic acid and 30 parts by weight of mesoporous calcium magnesium silicate at 100°C for 6 hours , mixed uniformly in a high-speed mixer, melt blended by a twin-screw extruder, and formed; wherein, the barrel temperature of each section of the extruder is 140-200 ° C, and the speed of the extruder is 100 rpm.

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Abstract

The invention discloses a mesoporous calcium magnesium silicate / polylactic acid composite material as well as a preparation method and a use thereof. The preparation method comprises the steps of drying raw materials, evenly mixing, carrying out melt blending and then molding, wherein the raw materials include 1-50wt% of mesoporous calcium magnesium silicate and 50-99wt% of polylactic acid. The preparation method of the mesoporous calcium magnesium silicate / polylactic acid composite material is simple in process, and the obtained mesoporous calcium magnesium silicate / polylactic acid composite material contains no other toxic small molecules and impurities, and has excellent biological activity and compatibility and appropriate mechanical properties; besides, the ratio of the mesoporous calcium magnesium silicate to the polylactic acid in the mesoporous calcium magnesium silicate / polylactic acid composite material is adjusted to meet the requirement on different degradation velocities of implant materials in different bone repair environments.

Description

technical field [0001] The invention relates to a mesoporous calcium magnesium silicate / polylactic acid composite material and its preparation method and application. Background technique [0002] At present, the materials used for bone repair mainly include metals, ceramics and polymers. Among them, most of the metal bone repair materials and ceramic bone repair materials are not biodegradable, which are easy to cause bone atrophy or even osteonecrosis; while the existing polymer implant materials lack biological activity, and there are problems that cannot be integrated with bone. defect. [0003] As a mesoporous material, mesoporous calcium magnesium silicate has the characteristics of high specific surface area, high pore volume and ordered mesoporous channels, and it can also directly combine with bone, which is a bone repair material with good biological activity. . However, mesoporous calcium magnesium silicate also has some defects common to mesoporous materials, ...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08K7/26A61L27/18A61L27/02
Inventor 唐颂超季加进魏杰王钰涛雷凯赵雁军陈莜陈梅春李晨
Owner EAST CHINA UNIV OF SCI & TECH
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