Pharmaceutical composition for treating rhinitis
A composition and drug technology, which can be used in drug combinations, active ingredients of heterocyclic compounds, antipyretic drugs, etc., can solve problems such as large side effects and lack of non-specific treatment for successful treatment cases.
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Embodiment 2
[0040] Example 2: Preparation of nasal spray or nasal lotion formulation containing citral (1%).
[0041]
[0042] Pour 45kg of pure water into a suitable mixing container with a mixer, and rotate and mix microcrystalline cellulose RC591 at high speed. Then, polysorbate, sorbitol solution, sodium ethylenediaminetetraacetate, and germine were sequentially dissolved and stirred.
[0043] Subsequently, the active ingredient citral is added and mixed with rapid stirring until a homogeneous suspension is produced. The volume was increased to 50 liters with purified water and further mixed. Finally the suspension was evacuated to remove the generated air bubbles. At this point, the resulting suspension is ready to be dispensed into vials.
Embodiment 3
[0044] Example 3: Nasal Spray or Nasal Drops Containing Azelastine Hydrochloride (0.1%, Dissolved) and Citral (1%, Suspended)
[0045]
[0046] Pour 45kg of pure water into a suitable mixing container with a mixer, and rotate and mix microcrystalline cellulose RC591 at high speed. Then, the active ingredient azelastine hydrochloride, the excipient polysorbate, the sorbitol solution, sodium edetate, and germine were successively dissolved and stirred.
[0047] Subsequently, the active ingredient citral is added and mixed with rapid stirring until a homogeneous suspension is produced. The volume was increased to 50 liters with purified water and further mixed. Finally the suspension was evacuated to remove the generated air bubbles.
[0048] At this point, the resulting suspension is ready to be dispensed into vials.
[0049] According to the effect spectrum of some antihistamines and citral, it can be seen that the combined formulation of the two substances has a synergis...
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