A kind of preparation method of 2,3,5-tricarboxycyclopentyl acetic acid
A technology of cyclopentyl acetic acid and tricarboxylate, which is applied in the field of preparation of 2,3,5-tricarboxycyclopentyl acetic acid, can solve the problems of slow ozone oxidation, low product purity, difficulty in large-scale production, and the like, To achieve the effect of fast reaction speed and high product purity
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preparation Embodiment 1
[0046] Add 10g of dicyclopentadiene to a mixed solution of 200ml of tetrahydrofuran and 200ml of water, add 70g of sodium periodate and 0.02g of osmium tetroxide, stir at room temperature for 20 hours, pour into 2000ml of water, precipitate a solid, and filter. Add 100ml of acetic acid, 100ml of water, and 20ml of 50% hydrogen peroxide to the solid, slowly raise the temperature to reflux, and react for 3 hours. Add 10ml of 50% hydrogen peroxide and react for 2 hours, then add 10ml of hydrogen peroxide and react for 20 hours. The solution was distilled under reduced pressure to obtain 17.1 g of a transparent viscous liquid, namely the product 2,3,5-tricarboxycyclopentylacetic acid.
preparation Embodiment 2
[0048] Add 10 g of dicyclopentadiene to a mixed solution of 900 ml of tetrahydrofuran and 100 ml of water, add 200 g of sodium periodate and 0.02 g of osmium tetroxide, stir at room temperature for 20 hours, pour into 4000 ml of water, precipitate a solid, and filter. Add 200ml of propionic acid, 100ml of water, and 20ml of 50% hydrogen peroxide to the solid, slowly raise the temperature to reflux, and react for 3 hours. Add 10ml of 50% hydrogen peroxide and react for 2 hours, then add 10ml of hydrogen peroxide and react for 20 hours. The solution was distilled under reduced pressure to obtain 16.3 g of a transparent viscous liquid, namely the product 2,3,5-tricarboxycyclopentylacetic acid.
preparation Embodiment 3
[0050] Add 10 g of dicyclopentadiene to a mixed solution of 200 ml of tetrahydrofuran and 200 ml of water, add 60 g of sodium periodate and 0.02 g of osmium tetroxide, stir at room temperature for 20 hours, pour into 2000 ml of water, precipitate a solid, and filter. Add 100ml of ethanol, 200ml of water, and 20ml of 50% hydrogen peroxide to the solid, slowly raise the temperature to reflux, and react for 3 hours. Add 10ml of 50% hydrogen peroxide and react for 2 hours, then add 10ml of hydrogen peroxide and react for 20 hours. The solution was distilled under reduced pressure to obtain 15.2 g of a transparent viscous liquid, namely the product 2,3,5-tricarboxycyclopentylacetic acid.
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