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s‑acetyl‑l‑glutathione crystals i and ii

A technology of glutathione and crystal, applied in the field of chemistry, can solve the problem that the crystal structure of the compound has not been reported.

Active Publication Date: 2017-01-18
DEMOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Although S-acetyl-L-glutathione has been used, the crystal structure of this compound has not been reported

Method used

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  • s‑acetyl‑l‑glutathione crystals i and ii
  • s‑acetyl‑l‑glutathione crystals i and ii
  • s‑acetyl‑l‑glutathione crystals i and ii

Examples

Experimental program
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Effect test

Embodiment 1

[0029] First, S-acetyl-L-glutathione was prepared according to published literature. In this example, S-acetyl-L-glutathione was prepared by using the method described in the patent application of the People's Republic of China with application number 201410310430.3, and the obtained S-acetyl-L-glutathione product was a white solid. Take 10 g of the white solid, place it in 100 ml of a mixture of acetone and water at a volume ratio of 1:1, and heat it to 60° C., the white solid completely dissolves. The reaction system was cooled in an ice-water bath, and crystals were precipitated. After filtration, 9.5 g of crystal product was obtained, and the yield of the crystal was 95%.

Embodiment 2

[0031] Take 10 g of the white solid of S-acetyl-L-glutathione prepared in Example 1, place it in 100 ml of a mixture of ethanol and water with a volume ratio of 1:1, and heat it to 60° C., the white solid is completely dissolved. The reaction system was cooled in an ice-water bath, and crystals were precipitated. After filtration, 9.2 g of crystal product was obtained, and the yield of the crystal was 92%.

[0032] The crystal obtained in embodiment 1 and embodiment 2 carries out X-ray diffraction experiment, finds that both X-ray diffraction Figure 1 Consistently, it was confirmed that the two crystals had the same structure, and they were named as type I crystals of S-acetyl-L-glutathione. figure 1 It is the X-ray diffraction pattern of type I crystal. The X-ray source corresponding to the diffraction pattern is Cu / K-α1, and the incident wavelength λ is 1.54056 angstroms. The X-ray diffraction pattern is represented by 2θ, d and relative intensity greater than 15% (θ is...

Embodiment 3

[0036] Prepare S-acetyl-L-glutathione type I crystal 10g according to the method of embodiment 1 or embodiment 2, place in 10mlH 2 O, heated to 80 ° C, all the I-type crystals dissolved. The reaction system was cooled to room temperature, and 100 ml of anhydrous tetrahydrofuran was added, and crystals were precipitated. After filtration, 7.4 g of crystal product was obtained, and the yield of the crystal was 74%.

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Abstract

The invention provides a crystal I and a crystal II of S-acetyl-L-glutathione. The crystal I and the crystal II adopt two different crystal structures, the stability of the crystal II is higher than that of the crystal I, and compared with the crystal II, the crystal I is simple in preparation method and low in cost.

Description

technical field [0001] The present invention relates to different crystal structures of the compound S-acetyl-L-glutathione and belongs to the field of chemistry. Background technique [0002] L-Glutathione, formula C 20 h 32 N 6 o 12 S 2 , CAS No. 27025-41-8. L-glutathione is composed of glutamic acid, cysteine ​​and glycine, which can assist the body's immune system to maintain normal functions, and has anti-oxidation, integrated detoxification and other functions. L-glutathione is currently used as a drug in the United States and other countries, and the approval process is relatively strict. S-acetyl-L-glutathione, chemical formula Molecular formula C 12 h 19 N 3 o 7 S, CAS No. 3054-47-5. In recent years, studies have found that oral administration of S-acetyl-L-glutathione can increase the content of L-glutathione in the body, and S-acetyl-L-glutathione can be used as both a drug and a food additive in many countries Management is increasingly becoming an ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/037C07K1/14A61K38/07A61P37/00A61P39/06A61P39/02A23L33/18
Inventor 周士虎谭玉霞金潇韩福庆曹宜宾姚颖律嵩
Owner DEMOTECH INC
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