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Application of composition in preparation of osteoporosis improvement products

A technology for osteoporosis and composition, which is applied in the field of application of composition in the preparation of products for improving osteoporosis, which can solve the problems of poor absorption effect, difficulty in patient acceptance, and inability to play a role, so as to achieve simple production process and promote osteoporosis. The effect of growth and relaxation

Inactive Publication Date: 2014-12-17
SUZHOU SCISCAPE BIO PHARMA TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcitonin has a certain effect on osteoporosis, but it is expensive and difficult to be accepted by the majority of patients
The absorption effect of calcium preparations and vitamin D is not good, and they cannot play a significant role, and long-term use or improper use may lead to stones

Method used

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  • Application of composition in preparation of osteoporosis improvement products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the combination mode of the composition of the present invention

[0031] Weigh the corresponding raw materials according to the weight ratios of seaweed substances and enzyme inhibitors in Table 1, and mix them directly to form a powder composition, or dissolve them in water to make a composition solution after mixing. The validamycin of the embodiment can be one or more mixtures of validamycin A-H (there is no difference in the inhibitory effect of enzymes using different isomers), mainly validamycin A; trehalose is trehalose (α , α), a mixture of isotrehalose (β, β) and neotrehalose (α, β).

[0032] The combination mode of table 1 composition of the present invention

[0033]

[0034] Composition 3

[0035] Further, the solid composition or composition solution can be used to make preparations by conventional methods, not listed one by one.

experiment example

[0036] Experimental example: the absorption situation of the composition of the present invention in the body

[0037] 1. Experimental animals and materials

[0038] Male ICR mice, 8 weeks old, weighing 20±2g, were purchased from Beijing Huafukang Experimental Animal Company;

[0039] The composition of this experimental example:

[0040] Composition 1 solution: Take 15g of trehalose and 3mg of validamycin, and prepare a composition 1 solution with 100mL of medical sterile water for use.

[0041] 2. Experimental method

[0042] After feeding the mice normally for 3 days, they were fasted for 12 hours without water, and randomly divided into 4 groups according to the blood sugar level, blank control group, drug treatment group, and negative control group 1-2. The administration group was given this experimental example composition 1 solution by intragastric administration according to the amount of 13.3mL / kg according to the body weight of the mice; 2 Inject 0.15 g / mL treha...

Embodiment 2

[0046] Embodiment 2, composition improves the effect of osteoporosis on castrated rats

[0047] 1. Experimental animals and materials

[0048] Female SD rats, weighing 250g-280g, were purchased from Shanghai Xipuer-Bikay Animal Company;

[0049] The present embodiment composition solution:

[0050] Composition 1 solution: Take 15g of trehalose and 3mg of validamycin, and prepare a composition 1 solution with 100mL of medical sterile water for use;

[0051] Composition 2 solution: take 300g of trehalose and 3mg of validamycin, and prepare a composition 2 solution with 100mL of medical sterile water for use;

[0052] Composition 3 solution: take 600g of trehalose and 3mg of validamycin, and prepare a composition 3 solution with 100mL medical sterile water, and set aside;

[0053] Composition 4 solution: take 15g of trehalose and 3mg of hexaconazole, and prepare a composition 4 solution with 100mL of medical sterile water for use;

[0054] Composition 5 solution: take 15g of ...

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Abstract

The invention discloses an application of a composition in the preparation of osteoporosis improvement products. The composition includes a seaweed substance and an enzyme inhibitor. The composition of the invention can increase the bone density and the mineral content of femur bones of ovariectomized rats and improve the osteoporosis condition of the rats; the seaweed substance has wide source and low price; and the osteoporosis improvement products prepared by using the composition can increase the bone density and the mineral content and promote skeletal growth, have the advantages of fast acting, good absorption, mild effect, obvious dose effect relationship and no toxic side effects, can be processed to prepare various oral forms convenient for patients to use, and are safe and effective for the patients.

Description

technical field [0001] The invention relates to the field of medicine and health care, in particular to the application of a composition in the preparation of products for improving osteoporosis. Background technique [0002] Osteoporosis, also known as osteoporosis (osteoporosis, OP) is caused by a variety of reasons and is characterized by a decrease in the amount of bone tissue per unit volume and degeneration or destruction of the microstructure of bone tissue, resulting in increased bone fragility and fracture risk. An increased systemic metabolic bone lesion. Its basic pathological mechanism is the defect in the coupling of bone resorption and bone formation in the process of bone metabolism, which leads to the imbalance of calcium and phosphorus metabolism in the human body and the clinical symptoms caused by the gradual decrease of bone density. In most cases of osteoporosis, the loss of bone tissue is primarily due to increased bone resorption. The onset is mostly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/734A23L1/29A23L2/39A23L2/38A61P19/10A23L33/00
Inventor 张成岗李志慧李雨
Owner SUZHOU SCISCAPE BIO PHARMA TECH
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