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Staged action antibacterial hydrogel dressing and preparation method thereof
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A hydrogel, staged technology, applied in the field of medicine, can solve problems such as waterproofing and promoting insufficient wound healing
Active Publication Date: 2016-07-06
ARNOKANG NINGXIA BIOTECH
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Problems solved by technology
However, most of the current hydrogel dressings are single-layer or double-layer, and the double-layer has an antibacterial layer and a water-absorbing layer. The existing hydrogel dressings are insufficient in waterproofing and promoting wound healing, and only a small part has antibacterial effects.
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Embodiment 1
[0044] A preparation method for staged antibacterial hydrogel dressing, comprising the steps of:
[0045] 1) Preparation of antibacterial layer: preparation of nano-silver / sodium polyacrylate mixed colloid
[0046] Dilute the synthesized nano-silver into a 100mL volumetric flask with a concentration of 100mg / L, weigh 2.0g of sodium polyacrylate and add it to the nano-silver solution, and stir while adding until the colloid is completely formed.
[0047] Put it into an oven at 60°C and dry it under vacuum for 20 minutes until an antibacterial layer with proper viscosity is obtained.
[0049] Weigh 0.2 g of pearls and 0.2 g of bezoar and dissolve them in 100 mL of carboxymethyl chitosan solution, slowly add 2 g of sodium polyacrylate into the solution, and stir while adding until a transparent colloid i...
Embodiment 2
[0056] The preparation method of the present embodiment is basically the same as that of Example 1, except that:
[0057] In the step 1), the concentration of the nano-silver solution is 150 mg / L, and the dosage of the sodium polyacrylate is 1.5 g; the drying temperature is 50° C., and the drying time is 30 minutes.
[0058] In the step 2), 1.5 g of sodium polyacrylate, 0.5 g of pearl powder, and 0.3 g of bezoar are used, and the drying temperature is 70° C., and the drying time is 5 hours.
[0060] In the step 4), the drying is to put the mixed layer into a 40° C. oven and bake continuously for 5 hours.
Embodiment 3
[0062] The preparation method of the present embodiment is basically the same as that of Example 1, except that:
[0063] In the step 1), the concentration of the nano-silver solution is 200 mg / L, and the dosage of the sodium polyacrylate is 1.8 g; the drying temperature is 70° C., and the drying time is 15 minutes.
[0064] In the step 2), 1.8 g of sodium polyacrylate, 0.3 g of pearl powder, and 0.5 g of bezoar are used, and the drying temperature is 50° C., and the drying time is 6 h.
[0066] In the step 4), the drying is to put the mixed layer into an oven at 50° C. and bake continuously for 3 hours.
[0067] The staged action antibacterial hydrogel dressing provided by the present invention has the characteristics of waterproof (reducing secondary trauma), staged effect ( antibacterial, promoting wound healing effect is remarkable) characteristics.
[0068] When it is applied to the diabetic wound infection m...
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Abstract
The invention discloses a stage-acting antibacterial hydrogel dressing and a preparation method thereof. The method comprises the following steps: preparing an antibacterial layer: adding sodium polyacrylate into a nano-silver solution and stirring to form a colloid; drying the colloid to obtain an antibacterial dressing layer; preparation of water-absorbing and sustained-release layer: dissolve pearl powder and bezoar in carboxymethyl chitosan solution to obtain a mixed solution, slowly add sodium polyacrylate into the mixed solution, and stir while adding until a transparent colloid is formed; preparation Waterproof and breathable layer: add polyvinyl butyralpowder into anhydrousethanol solution and dissolve to obtain a transparent liquid; assembly: pour the transparent liquid into a plate with a thickness between 1.5 and 2.5mm, and cover it with a layer of non-woven Then spread the transparent colloid of the water-absorbing and slow-release layer on the non-woven fabric to obtain a mixed layer, dry the mixed layer, make the transparent colloid and the transparent liquid bond together, and then stick the transparent colloid on the mixed layer. Connect the antibacterial layer. The invention has the advantages of remarkable effect of promoting wound healing.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a phase-acting antibacterial hydrogel dressing and a preparation method thereof. Background technique [0002] Medical dressings are wound dressings, medical materials used to cover sores, wounds or other damage. It can avoid the influence of bacterial infection and other external factors, and play a role in protecting the wound. The hydrogel in the hydrogel dressing can be firmly attached to the skin at the edge of the wound, and at the same time can absorb a large amount of wound exudate, which can solve the problem that the traditional gauze has too high permeability, which easily dehydrates and adheres to the wound surface, which will cause mechanical damage again when it is replaced. Injuries, microbes in the external environment are easy to pass through, and the chance of cross-infection is high. In addition, hydrogel dressings can also absorb wound exudate and some toxic substance...
Claims
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