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A kind of preparation method and application of yew extract

A technology of yew extract and yew, which is applied in the direction of drug combination, medical raw materials derived from gymnosperm subphylum, metabolic diseases, etc., can solve the problems that the dissolution rate needs to be improved, so as to speed up the extraction speed, reduce the process links, and reduce the The effect of energy consumption

Active Publication Date: 2017-08-18
无锡紫杉药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the extraction method of yew extract traditionally used in traditional Chinese medicine, the dissolution rate needs to be improved

Method used

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  • A kind of preparation method and application of yew extract

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Embodiment 1

[0030] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0031] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0032] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment, the power of the ultrasonic generator is 15-30KW, such as 20KW, the frequency is 20-25KHz, such as 23KHz, and the sound intensity is 2W / cm 2 , ultrasonic treatment for 30min to obtain feed liquid.

[0033] (3) enzymatic hydrolysis, the material liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.3%...

Embodiment 2

[0039] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0040] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0041] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment. The power of the ultrasonic generator is 15-30KW, such as 15KW, the frequency is 20-25KHz, such as 20KHz, and the sound intensity is 2W / cm 2 , ultrasonic treatment for 40min to obtain feed liquid.

[0042] (3) enzymatic hydrolysis, the feed liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.5% of ...

Embodiment 3

[0048] The preparation method of the yew extract of the present embodiment, comprises the steps:

[0049] (1) Prepare the raw material of yew, dry and crush the branches and leaves of yew, pass through an 80-mesh sieve, and the sieve is the raw material of yew, which is set aside.

[0050] (2) Ultrasonic wall breaking treatment, take the undersieve, that is, 10 kg of yew raw material, put it into an ultrasonic wall breaking extraction tank, add 15 times the weight of the yew raw material soaking agent—water, stir and soak at 50 ° C for 1 hour; Use an ultrasonic generator for ultrasonic wall breaking treatment, the power of the ultrasonic generator is 15-30KW, such as 30KW, the frequency is 20-25KHz, such as 25KHz, and the sound intensity is 3W / cm 2 , ultrasonic treatment for 30min to obtain feed liquid.

[0051] (3) enzymatic hydrolysis, the feed liquid is transferred to the reaction vessel—that is, in the stirring extraction tank, and neutral protease accounting for 0.8% of ...

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Abstract

The invention discloses a preparation method of a yew extract, which comprises the following steps: (1) preparing yew raw materials; (2) ultrasonic wall-breaking treatment, stirring and soaking the yew raw materials in a soaking agent to obtain a soaking liquid. The soaking liquid is subjected to ultrasonic wall-breaking treatment to obtain a feed liquid; (3) enzymatic hydrolysis, the feed liquid is transferred to a reaction vessel, and 0.3% to 1.0% of yew raw material weight is added to the reaction vessel. Neutral protease to obtain a mixed solution, adjust the pH of the mixed solution to 6.8-7.0, enzymolyze the free protein in the glycoprotein and polysaccharide to hydrolyze, inactivate the enzyme, and obtain a slurry; (4) perform reflux extraction on the slurry, The extract is obtained, filtered and concentrated to obtain a concentrate, and the concentrate is filtered to obtain a filtrate; (5) spray-dried to obtain a yew extract. The preparation method improves the dissolution rate and accelerates the extraction speed.

Description

technical field [0001] The invention relates to a preparation method of a yew extract, and also relates to the application of the yew extract, which belongs to the field of medicinal plant development. Background technique [0002] Taxus is the general name of Taxus genus Taxus. The medicinal value of yew has been recorded in "Compendium of Materia Medica", and it is mainly used for the treatment of cholera, typhoid and for detoxification. It is recorded in "Modern Dictionary of Traditional Chinese Medicine" and "Materia Medica Tui Chen" that its nature and taste are bitter, flat, and slightly poisonous. Modern Chinese medicine also uses it to treat diabetes, kidney disease and gynecological diseases. More than 400 compounds have been isolated from yew plants, the main components are taxanes and non-taxanes. Taxanes are taxane diterpenoids, and non-taxanes are mainly triterpenes, steroids, homoterpenes, flavonoids, phenylpropanoids, and phenols. In my country's tradition...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/13A61P35/00A61P3/10A61P37/04A61P3/06A61P9/12A61P29/00A61P9/10
Inventor 田连忠刘雷葛月兰
Owner 无锡紫杉药业股份有限公司