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Application of total anthraquinone and composition thereof to treatment of Alzheimer's diseases

A technology for total anthraquinone of rhubarb and Alzheimer's disease, which is applied in the field of total anthraquinone of rhubarb and can solve the problems of poor extraction effect of free anthraquinones and the like

Inactive Publication Date: 2015-01-07
JIANGXI BAISHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern chemical research proves that the main chemical components of rhubarb are anthraquinone compounds; the extraction and separation methods of rhubarb active ingredients mainly include: decoction method (water extraction method): decoction method is the traditional extraction method of rhubarb active ingredients, due to free anthraquinone The polarity of anthraquinones is small, so the extraction effect of free anthraquinones is not good by decoction; while the polarity of its combined anthraquinone glycosides is larger than that of its aglycones, so it can be extracted with water

Method used

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  • Application of total anthraquinone and composition thereof to treatment of Alzheimer's diseases
  • Application of total anthraquinone and composition thereof to treatment of Alzheimer's diseases
  • Application of total anthraquinone and composition thereof to treatment of Alzheimer's diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110]

[0111] The preparation method of the rhubarb total anthraquinone capsule of invention is as follows:

[0112] 1) Rhubarb total anthraquinones, microcrystalline cellulose, mixed evenly;

[0113] 2) Povidone is dissolved in 95% (v / v) ethanol, prepared to contain 10% povidone solution (10 parts by weight of povidone are dissolved in 95% ethanol to obtain 100 parts by volume of povidone Ketone ethanol solution);

[0114] 3) Add 10% povidone solution into the above mixture and stir evenly, make soft material, sieve through 18 meshes to make granules, dry, add magnesium stearate after granules are dry, mix evenly, pack 1000 capsules.

Embodiment 2

[0116] The recipe is

[0117]

[0118] The preparation method is as follows:

[0119] 1) Rhubarb total anthraquinones, microcrystalline cellulose, mixed evenly;

[0120] 2) Povidone is dissolved in 95% (v / v) ethanol, prepared to contain 10% povidone solution (10 parts by weight of povidone are dissolved in 95% ethanol to obtain 100 parts by volume of povidone Ketone ethanol solution);

[0121] 3) Add 10% povidone solution into the above mixture and stir evenly to make a soft material, pass through an 18-mesh sieve to make granules, dry, add magnesium stearate after the granules are dry, mix evenly, and press 1000 tablets.

Embodiment 3

[0123] The recipe is

[0124]

[0125] The preparation method is as follows:

[0126] 1) Rhubarb total anthraquinones, microcrystalline cellulose, mixed evenly;

[0127] 2) Povidone is dissolved in 95% (v / v) ethanol, prepared to contain 10% povidone solution (10 parts by weight of povidone are dissolved in 95% ethanol to obtain 100 parts by volume of povidone Ketone ethanol solution);

[0128] 3) Add 10% povidone solution into the above mixture and stir evenly, make soft material, sieve through 18 meshes to make granules, dry, add magnesium stearate after granules are dry, mix evenly, pack 1000 capsules.

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PUM

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Abstract

The invention relates to an application of total anthraquinone and a composition thereof to treatment of Alzheimer's diseases. The total anthraquinone comprises free anthraquinone, combined anthraquinone, anthrone, sugar, tannin or a mixture of the materials.

Description

Technical field: [0001] The invention relates to a therapeutic use of a traditional Chinese medicine extract preparation, in particular to a rhubarb total anthraquinone preparation which uses the rhubarb total anthraquinone extracted from the traditional Chinese medicine rhubarb as an active ingredient and its new therapeutic use. Background technique: [0002] Rhubarb is one of the commonly used traditional Chinese medicines. It is the dried root and rhizome of rhubarb palmatum, rhubarb tangutica or medicinal rhubarb, which is a perennial herb of Polygonaceae. [0003] Rhubarb is bitter in taste, cold in nature, and has the effects of purging and attacking, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and stimulating menstruation. Modern chemical research proves that the main chemical components of rhubarb are anthraquinone compounds; the extraction and separation methods of rhubarb active ingredients mainly include: decoction method ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61P25/28
CPCA61K36/708A61K9/28A61K9/4866A61K2236/333A61K2236/55G01N21/31G01N30/02G01N30/90
Inventor 付诚付志高
Owner JIANGXI BAISHEN PHARMA
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