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Microfluidics droplet detection system and method based on capacitive sensor

A capacitive sensor and detection system technology, applied in the direction of material capacitance, instruments, measuring devices, etc., can solve the problems of changes in the biochemical activity of analytical substances, inability to accurately control droplets, unfavorable integration, etc.

Inactive Publication Date: 2015-01-07
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, fluorescent labeling may cause changes in the biochemical activity of the analyte and affect the reliability of the results.
The photomultiplier tube detects the average information of the droplet, and cannot precisely control the droplet
Moreover, the above two detection methods require large-scale experimental instruments, which is not conducive to integration

Method used

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  • Microfluidics droplet detection system and method based on capacitive sensor
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  • Microfluidics droplet detection system and method based on capacitive sensor

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Embodiment

[0051] Embodiment: A microfluidic droplet detection system based on a capacitive sensor, characterized in that it includes a droplet microfluidic chip, a DC voltage stabilization circuit unit, a signal detection circuit unit, and a computer; wherein the droplet microfluidic The control chip is a chip structure that integrates the capacitive sensor and the microchannel that produces the micro-droplet; figure 1 ); the lower sheet is a microchannel sheet, welded with sample I inlet, sample II inlet 3, droplet outlet 4, intersection 6, electrode terminal, sample I channel, sample II channel 11 and droplet generation channel 12 The sample I inlet is connected to the sample I channel; the sample II inlet 3 is connected to the sample II channel 11; the sample I channel and the sample II channel 11 are connected to the droplet generation channel 12 through the intersection 6; The droplet generating channel 12 is connected to the droplet outlet 4; the capacitive sensor 5 is placed abo...

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Abstract

A microfluidics droplet detection system based on a capacitive sensor is characterized by comprising a droplet microfluidics chip, a direct-current voltage stabilizing circuit unit, a signal detection circuit unit and a computer, and the droplet microfluidics chip is of a structure according to which the capacitive sensor is integrated with a microchannel used for generating micro-droplets. A droplet detection method comprises the steps of sample pumping, droplet formation and droplet detection. The system and method have the advantages that the structure is simple, detection is conducted by means of the change of the capacitance, detection is quick, the size of the system is small, integration can be realized, the system and method are suitable for analysis of expensive samples and reagents, and manufacturing and implementation are easy.

Description

(1) Technical field: [0001] The invention belongs to the field of microfluidic chip analysis, in particular to a capacitive sensor-based microfluidic droplet detection system and detection method. (two) background technology: [0002] The microfluidic chip integrates the basic operation units involved in the fields of biology and chemistry, such as sample preparation, reaction, separation, detection, cell culture, sorting, and lysis, on a chip of several square centimeters. A network of microchannels is formed to run through the entire system with controllable fluids to replace various functions of conventional chemical or biological laboratories. The biggest advantage of microfluidic chips is the flexible combination and large-scale integration of various unit technologies on an overall controllable micro platform, which makes microfluidic chips likely to become an important platform for the development of biochemical analysis technology in the future. Droplet microfluidic...

Claims

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Application Information

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IPC IPC(8): G01D21/02G01N27/22
Inventor 魏巍吴方郭书祥
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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