Multifunctional photoelectrochemical sensor based on G-tetrahedron/hemin

A photoelectrochemical, tetrahedral technology, applied in the direction of material electrochemical variables, etc.
CN104297306AActive Publication Date: 2015-01-21JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2015-01-21

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Abstract

The invention relates to a novel and multifunctional photoelectrochemical sensor which is capable of triggering the light current of a water-soluble PbX (X represents sulfur or selenium) quantum dot to be increased based on G-tetrahedron / hemin. The G-tetrahedron / hemin is formed on the surface of the PbX (X represents sulfur or selenium) quantum dot by the specific identification reaction between a target object to be measured and nucleic acid recognition molecules fixed on the surface of an electrode. The G-tetrahedron / hemin compound is taken as an electron acceptor of the quantum dot and is used for carrying out catalytic reduction on dissolved oxygen, so that the separation efficiency of the photo-induced charges of the quantum dot can be improved, and the light current of the PbX (X represents sulfur or selenium) quantum dot can be increased. According to the multifunctional photoelectrochemical sensor, multiple target objects (such as DNA, thrombin, triphosadenine, adenosine monophosphate and lead (II) ions) are unmarked by selecting nucleic acid probes with different sequences; the multifunctional photoelectrochemical sensor is simple, convenient and high in sensitivity and selectivity when being used for measurement.
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Description

Technical field:

[0001] The invention relates to the field of nanometer analysis and detection, in particular to the application of water-soluble PbX (X represents sulfur and selenium) quantum dots as modified electrodes in photoelectrochemical analysis. Background technique:

[0002] It is an urgent task for analytical chemistry to establish a rapid detection method for target molecules with high sensitivity, high throughput and strong specificity. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) not only store and transmit genetic information, but also interact with other types of molecules through their own spatial structure. Nucleic acid aptamers (aptamers) are screened out by Systematic Evolution of Ligands by Exponential enrichment (SELEX). Nucleic acid fragments (single-stranded DNA or RNA), which have high affinity and specific recognition ability for target molecules [Goulko A A, Li F, Le X C. Trends Anal. Chem., 2009, 28: 878-892.] . Aptamers do not depend...

Claims

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