Low-toxicity acanthopanax injection and preparation method thereof

A technique for injection of Acanthopanax senticosus and injection, which is applied in the field of injection of Acanthopanax senticosus with low toxicity, and can solve the problems such as control of potassium ion content of medicines that are not mentioned.

Active Publication Date: 2015-01-28
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the existing Chinese patents, such as CN201210049755.1 (hereinafter referred to as the 2012 patent), disclose a kind of Acanthopanax acanthopanax composition containing its preparation and its detection method, all of which do not mention the problem of controlling the content of potassium ions in the medicine.

Method used

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  • Low-toxicity acanthopanax injection and preparation method thereof

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Effect test

Embodiment 1

[0053] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0054] (1) Extraction: extract 6 kg of Acanthopanax senticosus medicinal material 3 times with 12 volume times of water (72 L), extract for 1 hour each time, combine the extracts, concentrate to obtain Acanthopanax senticosus water decoction, and set aside;

[0055] (2) Primary alcohol precipitation: under stirring conditions, add 95% ethanol (to make the alcohol content reach 75%) to the Acanthopanax senticosus water decoction obtained in step (1), fully stir, and leave standstill for 6 hours; filter, and filtrate Recover ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.15 (measured at 80°C), and obtain a primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is set aside;

[0056] (3) Lithium-sulfur method treatment: Take an appropriate amount of the alcohol-precipitated paste of the Acanthopanax senticosus extract obtained in step (...

Embodiment 2

[0060] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0061] (1) Extraction: extract 8 kg of Acanthopanax senticosus medicinal material 2 times with water (64 L) of 8 times the volume, extract 2 hours each time, combine the extracts, concentrate to obtain Acanthopanax senticosus water decoction, and set aside;

[0062] (2) Primary alcohol precipitation: under stirring conditions, add 93% ethanol (to make the alcohol content reach 74.5%) to the Acanthopanax senticosus water decoction obtained in step (1), fully stir, leave standstill for 12 hours, filter, and the filtrate Recover ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.11 (measured at 80°C), and obtain a primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is set aside;

[0063] (3) Lithium-sulfur method treatment: Take an appropriate amount of the alcohol-precipitated paste of the Acanthopanax senticosus extract obtained in ste...

Embodiment 3

[0067] Embodiment 3: Preparation of Acanthopanax Acanthopanax Extract

[0068] (1) Extraction: extract 10kg of Acanthopanax senticosus medicinal material 2 times with water (120L) of 12 times the volume, extract for 1.5 hours each time, combine the extracts, concentrate to obtain Acanthopanax senticosus water decoction, and set aside;

[0069] (2) Primary alcohol precipitation: under stirring conditions, add 95% ethanol (to make the alcohol content reach 75.5%) to the Acanthopanax senticosus water decoction obtained in step (1), fully stir, leave standstill for 18 hours, filter, and the filtrate Recover ethanol until there is no alcohol smell, continue to concentrate until the relative density is 1.14 (measured at 80°C), and obtain a primary alcohol-precipitated paste of Acanthopanax acanthopanax extract, which is set aside;

[0070] (3) Lithium-sulfur method treatment: Take an appropriate amount of the alcohol-precipitated paste of the Acanthopanax senticosus extract obtained...

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Abstract

The invention relates to a low-toxicity acanthopanax injection and a preparation method thereof. The acanthopanax injection is prepared from the following active ingredients: 1.8-5.5mg/ml of total flavonoids, 0.13-0.70mg/ml of syringin, 0.06-0.34mg/ml of eleutheroside E and less than or equal to 800micro g/ml of potassium ions. The acanthopanax injection is low in content of potassium ions, which is reduced from less than or equal to 1000 micro g/ml in the national standard to lower than 800 micro g/ml (or counting at 800micro g/5mg total flavonoids). The injection has the advantages of small abnormal toxicity and high safety. Animal experiments indicate that the tolerated concentration of a study subject is increased from 5mg/ml in the national standard to 18mg/ml. The abnormal toxicity inspection result on the low-toxicity acanthopanax injection provided by the invention is superior to the existing commercially available products.

Description

technical field [0001] The invention relates to Acanthopanax injection, in particular to a Acanthopanax injection with low toxicity. Background technique [0002] Acanthopanax is the dry root and rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of Araliaceae. It has the effects of invigorating qi, invigorating the spleen, invigorating the kidney and calming the nerves. Sexually pungent, slightly bitter, warm. Acanthopanax injection is a sterilized aqueous solution made by extracting Acanthopanax senticosus. It is used to treat transient ischemic attack, cerebral arteriosclerosis, cerebral thrombosis, and cerebral embolism caused by liver and kidney deficiency. It is also used to treat coronary heart disease, angina pectoris combined with neurasthenia and menopausal syndrome. [0003] Chinese medicine injections including Acanthopanax injection, as a new dosage form of Chinese medicine produced by the development of modern science and technology...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61K9/08
CPCA61K9/0019A61K9/08A61K36/254A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 方同华陈景超冯慧乔云峰许照芹刘玉成季庆亮席桂才周广红范玉奇
Owner HARBIN ZHENBAO PHARMA
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