Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of synthetic method of amino polycarboxylic acid compound ethylene glycol bis(2-aminoethyl ether) triacetic acid

A technology of amino ethyl ether and amino polycarboxylic acid, which is applied in the preparation of organic compounds, chemical instruments and methods, preparation of cyanide reactions, etc., to achieve the effect of increasing fat solubility

Active Publication Date: 2016-01-06
LIAONING UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the difficult problems in the synthesis of unsaturated asymmetric amino polycarboxylic acid compounds, the present invention provides a simple and novel synthesis of unsaturated asymmetric amino polycarboxylic acid compounds with low cost, no by-product formation and no environmental pollution. method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of synthetic method of amino polycarboxylic acid compound ethylene glycol bis(2-aminoethyl ether) triacetic acid
  • A kind of synthetic method of amino polycarboxylic acid compound ethylene glycol bis(2-aminoethyl ether) triacetic acid
  • A kind of synthetic method of amino polycarboxylic acid compound ethylene glycol bis(2-aminoethyl ether) triacetic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 by synthesizing H 3 eg3a-Eu 2 o 3 The complex gets H 3 eg3a

[0021] h 3 eg3a-Eu 2 o 3 Synthesis of the complex: the weighed H 4 egta (1.9017g, 5.00mmol) was added to 100mL of warm water, and Eu 2 o 3 Powder (0.8798g, 2.50mmol), the above mixed solution was heated to reflux in a magnetic stirrer for 3-4h, until the solution became clear and transparent, and cooled. Ethylenediamine solution was added dropwise to the solution to adjust the pH to 6.0. The solution was concentrated to 25.00mL and left to stand, at this time the unconverted H 4 egta-Eu 2 o 3 The complex exists as a precipitate, which is filtered to remove unconverted H 4 egta-Eu 2 o 3Complex, take the filtrate, the filtrate is mainly H 3 eg3a-Eu 2 o 3 Complex.

[0022] h 3 Synthesis of eg3a: Add sodium hydroxide solution dropwise to the filtrate, adjust the pH to 12.0-13.0, alkalinize and destroy H 3 eg3a-Eu 2 o 3 Complex. Stand still, filter and take the filtrate, get Na 3...

Embodiment 2

[0029] Example 2 by synthesizing H 3 eg3a-Tb 2 o 3 The complex gets H 3 eg3a

[0030] h 3 eg3a-Tb 2 o 3 Synthesis of the complex: the weighed H 4 egta (1.9017g, 5.00mmol) was added to 100mL of warm water, and then Tb was added to it 2 o 3 Powder (0.9146g, 2.50mmol), the above mixed solution was heated and refluxed in a magnetic stirrer for 3-4h, until the solution became clear and transparent, and cooled. Ethylenediamine solution was added dropwise to the solution to adjust the pH to 6.0. The solution was concentrated to 25.00mL and left to stand, at this time the unconverted H 4 egta-Tb 2 o 3 The complex exists as a precipitate, which is filtered to remove unconverted H 4 egta-Tb 2 o 3 Compound, take the filtrate.

[0031] h 3 Synthesis of eg3a: Add sodium hydroxide solution dropwise to the filtrate, adjust the pH to 12.0-13.0, alkalinize and destroy H 3 eg3a-Tb 2 o 3 Complex. Stand still, filter, get Na 3 eg3a solution, and then add concentrated hydroch...

Embodiment 3

[0034] Example 3 by synthesizing H 3 eg3a-Yb 2 o 3 The complex gets H 3 eg3a

[0035] h 3 eg3a-Yb 2 o 3 Synthesis of the complex: the weighed H 4 egta (1.9017g, 5.00mmol) was added to 100mL of warm water, and then Yb was added to it 2 o 3 Powder (0.9852g, 2.50mmol), the above mixed solution was heated to reflux in a magnetic stirrer for 3-4h, until the solution became clear and transparent, and cooled. Methylamine solution was added dropwise to the solution to adjust the pH to 6.0. The solution was concentrated to 25.00mL and left to stand, at this time the unconverted H 4 egta-Yb 2 o 3 The complex exists as a precipitate, which is filtered to remove unconverted H 4 egta-Yb 2 o 3 Compound, take the filtrate.

[0036] h 3 Synthesis of eg3a: Add potassium hydroxide solution dropwise to the filtrate, adjust the pH to 12.0-13.0, alkalinize and destroy H 3 eg3a-Yb 2 o 3 Complex. Stand still, filter, get K 3 eg3a solution, and then add concentrated hydrochloric...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a synthesis method of amino polycarboxylic compound ethylene glycol bis(2-amino ethylether) triacetic acid. According to the technical scheme adopted by the invention, the synthesis method of amino polycarboxylic compound ethylene glycol bis(2-amino ethylether) triacetic acid comprises the following steps: firstly dissolving ethylene glycol bis(2-amino ethylether) tetraacetic acid, adding rare-earth metal oxide, heating, stirring and reflowing for 3-4 hours to obtain a 3eg3a-Re2O3 compound solution, dropwise adding an organic amine to adjust pH value of the solution to be 5.0-6.0, concentrating the solution, standing, filtering to extract filtrate, dropwise adding a sodium hydroxide solution to adjust the pH to be 12.0-13.0, and alkalizing and breaking the 3eg3a-Re2O3 compound; standing, filtering, dropwise adding concentrated hydrochloric acid into the filtrate to adjust the pH to 2.0-3.0 so as to obtain a large quantity of H3eg3a precipitates. The method is simple, novel, low in cost and free of by-product; the pollution to the environment is avoided.

Description

technical field [0001] The invention belongs to the field of organic synthesis, in particular to a kind of unsaturated asymmetric amino polycarboxylic acid compound ethylene glycol bis(2-aminoethyl ether) triacetic acid (H 3 The synthetic method of eg3a). Background technique [0002] The synthesis and development of amino polycarboxylic acid compounds has been one of the research topics that many chemists are more interested in for many years. Amino polycarboxylic acid compounds are widely used in biomedicine (preparation of targeted drugs, etc.), pharmacy (synthesis of antineoplastic drugs and detoxification drugs, etc.), agriculture (applied to chemical and biosensors, etc.) and environmental detection (fluorescent probes, etc.) and other fields. Therefore it is quite necessary to develop new methods for the synthesis of aminopolycarboxylic acid compounds. [0003] At present, the types of saturated and symmetrical amino polycarboxylic acid compounds studied in the wor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/16C07C227/16
Inventor 王君李冰张朝红姜晓庆秦翠孔德勇
Owner LIAONING UNIVERSITY