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Chondroitin sulfate preparation process and equipment thereof

A chondroitin sulfate and preparation process technology, which is applied to the extraction process of 10,000-ton chondroitin sulfate by solvent-free method and its equipment, in the field of chondroitin sulfate preparation technology, can solve the problem of limited market capacity and application fields, and cannot realize automatic production. , less product variety and other problems, to achieve the effect of less labor, high degree of automation and high product quality

Active Publication Date: 2015-03-04
张木良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the design of the present invention is to provide a chondroitin sulfate preparation process and equipment thereof, which changes the uniqueness of the traditional CS extraction process by solvent method; The problem of automated production; changed the extraction process of CS production, with large investment, long cycle, high energy consumption, high pollution, high cost, and side effects (referring to people who are allergic to proteins, organic solvents, and hydrogen peroxide), resulting in product varieties Less (so far there is no CS oral liquid grade series), limited market capacity and application fields; save investment, compared with the same scale, it can save more than 80% of investment funds

Method used

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  • Chondroitin sulfate preparation process and equipment thereof
  • Chondroitin sulfate preparation process and equipment thereof
  • Chondroitin sulfate preparation process and equipment thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Such as figure 1 As shown, a preparation process of chondroitin sulfate, the specific operation steps are as follows:

[0045] (1) Liquefaction: Put the raw materials into the reactor, defrost and cook at a temperature of 100-120°C, liquefy after pressure cooking, and turn into a liquid state. The whole process takes about 1 to 3 hours;

[0046] Among them, the raw material is frozen fresh cartilage powder or cartilage mud; frozen fresh cartilage powder refers to the cartilage produced during the division process of different animals (such as cattle, pigs, sheep, chickens, ducks, sharks, etc.) after they have been slaughtered. Then it is processed to achieve no meat, oil, and impurities, and then crushed or minced, and stored in a square container according to a certain weight (such as 10-20 kg / piece) in quick-frozen refrigeration (-5~-20℃) , Serve mass cartilage powder;

[0047] (2) Extraction and enzymatic degradation: After cooling the cartilage liquid after liquefaction i...

Embodiment 2

[0053] A device used in the preparation process of chondroitin sulfate in Example 1 above, comprising a reaction kettle, the reaction kettle is preferably a Teflon reaction kettle, and the reaction kettle is connected with a vacuum circulation filter, a filtrate storage tank and Molecular sieve, the molecular sieve is connected with a protein liquid storage tank and a CS liquid storage tank respectively. The raw materials are first boiled, cooled, alkali hydrolyzed, enzymatically degraded and degraded in the reactor to complete the steps (1) and (2) of the above process, and then filter through the vacuum circulating filter to complete the step (3) of the above process , The filtrate is pumped into the filtrate storage tank, and then the material is pumped into the molecular sieve from the filtrate storage tank, and the material is separated to complete step (4) of the above process, and then the separated products are pumped into the protein liquid storage tank and In the CS l...

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Abstract

The invention discloses a chondroitin sulfate preparation process and equipment thereof and in particular relates to a process for extracting ten thousand tons of chondroitin sulfate by virtue of a solvent-free method. The process comprises the following steps: liquifying, extracting, performing enzymolysisdegrading, filtering, separating and performing after-treatment. The equipment comprises a reaction kettle, wherein the reaction kettle is preferably a Teflon reaction kettle; the reaction kettle is sequentially in pipeline connection with a vacuum circulation filter, a filtrate storage tank and a molecular sieve; and the molecular sieve is respectively in pipeline connection with a protein fluid storage tank and a CS solution storage tank. The chondroitin sulfate preparation process and the equipment thereof disclosed by the invention have the advantages that the investment is saved, and compared with that in the same scale, the invested capital can be saved by over 80 percent and the larger the scale is, the lower the relative investment is; the highest capacity can be over ten thousand tons, which is far higher than that of a solvent-process technology, and automatic and continuous production can be realized; the product quality is optionally controllable, the content (namely CPC content) is between 60 percent to 105 percent, and the other quality indexes can reach or exceed the existing product quality standard requirements; and moreover, pollution is avoided, zero emission is realized, and green and environment-friendly production is also realized.

Description

Technical field [0001] The invention relates to a preparation process of chondroitin sulfate, in particular to a solvent-free extraction process and equipment of 10,000-ton chondroitin sulfate, belonging to the field of chondroitin sulfate extraction. Background technique [0002] Chondroitin sulfate (CS for short) has been extracted and separated from animal cartilage by the Americans in 1861. The key to its extraction and purification technology is inseparable from organic solvents. The reason is that the physical properties of the product are soluble in Water is insoluble in organic solvents. Commonly used solvents are: acetone, ethanol, ether, chloroform, etc. Because of the toxic side effects of acetone, ether and chloroform, they were discarded. So far, the world's CS extraction and purification process technology is determined by the solvent concentration. The solvents used are acetone and ethanol. Because the boiling point of acetone solvent is too low, it is volatile ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/0069
Inventor 张木良
Owner 张木良