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Method for extracting dendrobine from dendrobe

A technology of Dendrobium and Dendrobium, which is applied in the field of medicine, can solve the problems of low product purity, high energy consumption, and low yield, and achieve the effects of simple process operation, high safety, and low price

Inactive Publication Date: 2015-03-25
WEIHAI NOVODA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to solve the problems of complex extraction and preparation of dendrobine in the prior art, low product purity, low yield, high energy consumption, etc., adopting the technology of extracting dendrobine from dendrobium, the process operation is simple, and the conditions are easy to achieve, The reagents used are non-toxic and harmless, safe and environmentally friendly, the product has high purity and good yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Crush Dendrobium, soak in 2% sulfuric acid aqueous solution as a solvent, 3 hours each time, filter, repeat the operation twice, combine the two soaking liquids, and concentrate under reduced pressure to a density of 1.10;

[0020] (2) Pass the concentrated soaking solution through D301-G macroporous weakly acidic styrene-based anion exchange resin, elute with 1% and 4% sodium hydroxide solution respectively, and concentrate under reduced pressure;

[0021] (3) Put the concentrated solution into 3% hydrochloric acid solution, stir for 4 hours at -3°C, crystallize, purify, filter, and repeat the operation twice;

[0022] (4) Vacuum drying the filtered product to obtain pure dendrobine.

Embodiment 2

[0024] (1) Crush Dendrobium, soak in 3% sulfuric acid aqueous solution as a solvent, filter for 3 hours each time, repeat the operation twice, combine the two soaking liquids, and concentrate under reduced pressure to a density of 1.08;

[0025] (2) Pass the concentrated soaking solution through D301-G macroporous weakly acidic styrene-based anion exchange resin, elute with 2% and 5% sodium hydroxide solution respectively, and concentrate under reduced pressure;

[0026] (3) Put the concentrated solution into 4% hydrochloric acid solution, stir at 0°C for 4 hours, crystallize, purify, filter, and repeat the operation twice;

[0027] (4) Vacuum drying the filtered product to obtain pure dendrobine.

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Abstract

The invention provides a method for extracting dendrobine from dendrobe. The method comprises the following steps: selecting reasonable macroporous resin to adsorb and an eluant to elute to obtain a relatively pure product; and finally, carrying out low-temperature crystallization by using a dilute hydrochloric acid solution to further purify the product so as to obtain high purity dendrobine, wherein the product is detected by virtue of high performance liquid chromatography, and the content of the obtained product is over 92%. The method provided by the invention is simple in process operation and the used raw materials and reagents are low in price, so that the safety is high.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a method for extracting dendrobine from dendrobium. Background technique [0002] Modern research shows that Dendrobium contains a variety of trace elements, which are closely related to the health and longevity of the human body. The anti-aging effect of Dendrobium on the human body is more extensive and comprehensive than that of general medicines on the human body. Modern medical research authorities also found that Dendrobium can indeed improve the body's immune function and enhance disease resistance. It is a rare and precious Chinese medicinal material, and its use and value will surely be recognized and applied by more and more people. Dendrobium is a very good health food and a medicinal material, which is deeply loved by the people. However, due to the very harsh growth conditions of Dendrobium officinale, the natural output is extremely scarce, and due to long-term over-harves...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/08
CPCC07D491/08
Inventor 王河东张庆卫李磊
Owner WEIHAI NOVODA PHARMA GRP
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