Non-invasive defection kit for screening susceptibility genes of endometrial carcinoma

A technology of endometrial cancer and a detection kit, which is applied in the determination/testing of microorganisms, biochemical equipment and methods, etc., and can solve problems such as changes in protein functions, affecting tumor growth, and changes in protein-coded amino acid sequences. The method is simple , reduce the probability of morbidity, and the results are accurate and reliable
CN104450876AInactive Publication Date: 2015-03-25TAIYUAN DEPTH DECODING GENE TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TAIYUAN DEPTH DECODING GENE TECH CO LTD
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a non-invasive detection kit for screening susceptibility genes of the endometrial carcinoma, belonging to the field of gene detection kits. The invention provides a detection kit which is painless, non-invasive, clean, less in possibility of causing cross infection, and accurate and reliable in result for detecting pathogenic factors and risk factors of endometrial carcinoma. The detection kit comprises a specific primer and a DNA sequencing primer for detecting the genotypes of mononucleotide polymorphic sites, a PCR (polymerase chain reaction) assembly, a PCR production purifying assembly and a DNA sequencing reaction assembly, wherein the specific primer is used for detecting a mononucleotide polymorphic site Msp on a CYP1A1 gene, a mononucleotide polymorphic site Leu432Va1 on a CYP1B1 gene, a mononucleotide polymorphic site MspA1I on a CYP17 gene, a mononucleotide polymorphic site 309 on an MDM2 gene and a mononucleotide polymorphic site C609T on a NQ01 gene. The non-invasive detection kit is mainly applied to the medical and the biological aspects.
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Description

technical field

[0001] The invention discloses a non-invasive detection kit for screening endometrial cancer susceptibility genes, belonging to the field of gene detection kits. Background technique

[0002] Endometrial cancer is a common malignant tumor of the female reproductive tract. It is the first among the three major malignant tumors of the female reproductive organs in European and American countries. After the 1960s in my country, the incidence rate began to increase and the trend of rejuvenation began. Endometrial cancer accounts for about 7% of women's malignant tumors, and its annual new cases and deaths account for 3.9% and 1.7% of women's malignant tumors respectively. Molecular genetic studies have shown that in endometrial cancer, cell proliferation is dysfunctional due to gradual changes in cell regulatory pathways such as activation of proto-oncogenes, inactivation of tumor suppressor genes, and changes in DNA mismatch repair genes.

[0003] Recent studie...

Claims

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