AWIA scoring model and building method thereof

Abstract

The invention belongs to the field of biotechnology, and particularly discloses an AWIA scoring model and a building method thereof. The building method is characterized by comprising the following steps: screening risk factors with difference between two groups through single factor analysis first; further selecting variables through a stepwise regression method to be taken as independent variables of multivariate Logistic analysis finally; obtaining a regression coefficient Beta of each independent variable after the multivariate Logistic analysis; adopting the lowest Beta value as a radix number to calculate multiples of the Beta values of the other independent variables to the independent variables, which are the corresponding scores of the independent variables; scoring a case group and a control group according to the scoring model; confirming critical scores with relatively high predictive value by drawing an ROC curve of a subject. After adoption of the model, diagnosis, treatment and rescue success rates of the AWIA are improved remarkably; the AWIA scoring model is further subjected to clinical practice and popularization.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a scoring model of airway invasive aspergillosis and a method for establishing the same. Background technique [0002] The lesions of airway invasive aspergillosis (AWIA) are limited to the trachea-bronchiole, accounting for nearly 1 / 3 of invasive pulmonary aspergillosis (IPA). At present, the diagnosis of AWIA patients is generally confirmed by pathology as airway Aspergillus infection. After bronchoscopy, biopsy samples from the lesion are sent to pathology and culture respectively to confirm the diagnosis. Because most AWIA patients have systemic and local immune dysfunction , Systemic application of antifungal drugs to the site of infection is limited, the control of airway Aspergillus infection is difficult, and the mortality rate is high. Therefore, only early diagnosis is needed to improve the understanding of AWIA and the level of early diagnosis, take active...

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Problems solved by technology

[0002] The lesions of airway invasive aspergillosis (AWIA) are limited to the trachea-bronchiole, accounting for nearly 1 / 3 of invasive pulmonary aspergillosis (IPA). At present, the diagnosis of AWIA patients is generally confirmed by pathology as airway Aspergillus infection. After bronchoscopy, biopsy samples from the lesion are sent to pathology and culture respectively to confirm the diagnosis. Because most AWIA patients have systemic and local immune dysfunction , the systemic application of antifungal drugs reaches the infection site with limited drug concentration, the control of airway aspergillus infection is difficult, and the mortality rate is high

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