AWIA scoring model and building method thereof

An invasive, aspergillosis technology, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of weak characteristics, low immune function, difficult control of airway aspergillus infection, etc. Objectivity and accuracy, and the effect of improving the success rate of diagnosis, treatment and rescue

Inactive Publication Date: 2015-03-25
JINHUA MUNICIPAL CENT HOSPITAL
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Problems solved by technology

[0002] The lesions of airway invasive aspergillosis (AWIA) are limited to the trachea-bronchiole, accounting for nearly 1/3 of invasive pulmonary aspergillosis (IPA). At present, the diagnosis of AWIA patients is generally confirmed by pathology as airway Aspergillus infection. After bronchoscopy, biopsy samples from the lesion are

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  • AWIA scoring model and building method thereof
  • AWIA scoring model and building method thereof
  • AWIA scoring model and building method thereof

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Embodiment Construction

[0014] The present invention is described in detail below in conjunction with embodiment:

[0015] A total of 51 patients diagnosed with AWIA were collected from Zhongshan Hospital affiliated to Fudan University and Jinhua Central Hospital, including 25 males and 26 females, aged 27-74 years, with an average age of 54 years. 51 patients who were diagnosed with IPA but not AWIA were selected to be hospitalized at the same time, including 24 males and 27 females, aged 16-84 years, with an average age of 59 years.

[0016] Sampling criteria for the above two groups of patients:

[0017] All patients in the AWIA group underwent bronchoscopy, biopsy samples from the lesion were sent to pathology and culture respectively, and the pathology and / or culture results met the following two criteria: ① Pleural effusion, bronchopulmonary tissue smear or culture were positive only once Confirmed diagnosis; fungal hyphae and spores were found in sputum or bronchial washing fluid, or the same...

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Abstract

The invention belongs to the field of biotechnology, and particularly discloses an AWIA scoring model and a building method thereof. The building method is characterized by comprising the following steps: screening risk factors with difference between two groups through single factor analysis first; further selecting variables through a stepwise regression method to be taken as independent variables of multivariate Logistic analysis finally; obtaining a regression coefficient Beta of each independent variable after the multivariate Logistic analysis; adopting the lowest Beta value as a radix number to calculate multiples of the Beta values of the other independent variables to the independent variables, which are the corresponding scores of the independent variables; scoring a case group and a control group according to the scoring model; confirming critical scores with relatively high predictive value by drawing an ROC curve of a subject. After adoption of the model, diagnosis, treatment and rescue success rates of the AWIA are improved remarkably; the AWIA scoring model is further subjected to clinical practice and popularization.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a scoring model of airway invasive aspergillosis and a method for establishing the same. Background technique [0002] The lesions of airway invasive aspergillosis (AWIA) are limited to the trachea-bronchiole, accounting for nearly 1 / 3 of invasive pulmonary aspergillosis (IPA). At present, the diagnosis of AWIA patients is generally confirmed by pathology as airway Aspergillus infection. After bronchoscopy, biopsy samples from the lesion are sent to pathology and culture respectively to confirm the diagnosis. Because most AWIA patients have systemic and local immune dysfunction , Systemic application of antifungal drugs to the site of infection is limited, the control of airway Aspergillus infection is difficult, and the mortality rate is high. Therefore, only early diagnosis is needed to improve the understanding of AWIA and the level of early diagnosis, take active...

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Application Information

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IPC IPC(8): G06F19/12
Inventor 陈慧
Owner JINHUA MUNICIPAL CENT HOSPITAL
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