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Processing method for increasing solubility and bioavailability of fat-soluble active component

A technology of active components and processing methods, which is applied in the field of processing to improve the solubility and bioavailability of fat-soluble active components, can solve problems such as difficult digestion and absorption by the human body, easy oxidation and decomposition, and poor water solubility, so as to improve bioavailability, Effect of improved solubility and low cost

Inactive Publication Date: 2015-04-01
JIANGNAN UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

However, many natural active ingredients have the characteristics of high melting point, poor water solubility, easy oxidative decomposition, and difficulty in being digested and absorbed by the human body. Therefore, designing an effective active ingredient delivery system to improve the utilization rate of biologically active substances is becoming a research focus in this field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Water-soluble starch particles (molecular weight 1.5×10 7 g / mol, molecular density 9.5%, average chain length DP 10.2, average particle size 80.4nm) dissolved in pH 7.0, 0.1mol / L sodium acetate buffer to make a homogeneous solution with a mass concentration of 5%; Carotene is dissolved in ethanol solution to make a homogeneous solution with a mass concentration of 5 mg / mL; the above two homogeneous solutions are mixed according to the total volume of the mixed solution of 200 mL, the weight ratio of water-soluble starch particles and fat-soluble active components to 200:1, and simultaneously Stir continuously at 70°C for 5 minutes at a constant temperature; place in an ultrasonic device, control the power at 600W, and process at 0°C for 20 minutes; centrifuge, and vacuum-dry the obtained supernatant to obtain lipids with good solubility. Soluble active ingredient-starch particle complex. The average particle size of the fat-soluble active component-starch particle com...

Embodiment 2

[0022] Water-soluble starch particles (molecular weight 1.0×10 8 g / mol, molecular density 7.1%, average chain length DP11.8, average particle size 98.6nm) dissolved in pH 7.0, 0.1mol / L sodium acetate buffer to prepare a homogeneous solution with a mass concentration of 30%; the coenzyme Dissolve Q10 in ethanol solution to make a homogeneous solution with a mass concentration of 300 mg / mL; mix the above two homogeneous solutions according to the total volume of the mixed solution of 200mL, and the weight ratio of water-soluble starch particles and fat-soluble active components to 2:1, and simultaneously Stir continuously at 30°C and react at a constant temperature for 120 minutes; place in an ultrasonic device, control the power at 200W, and process at 10°C for 2 minutes; centrifuge, and vacuum-dry the obtained supernatant to obtain lipids with good solubility. Soluble active ingredient-starch particle complex. Zetasizer Nano ZS was used to measure the particle size of the fa...

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Abstract

The invention discloses a processing method for increasing the solubility and the bioavailability of a fat-soluble active component and belongs to the technical field of processing of modern nutritional foods.Water-soluble starch particles are used as carriers, and a nanoscale fat-soluble active component-starch particle compound is prepared with a nano suspension technology, so that the water solubility as well as absorption and utilization effects of the fat-soluble active component are improved. The method can significantly increase the solubility and the bioavailability of insoluble food active components and can be applied to various fields of foods, medicines, daily chemicals and the like.

Description

technical field [0001] The invention relates to a processing method for improving the solubility and bioavailability of fat-soluble active components, and belongs to the technical field of modern nutritional food processing. Background technique [0002] With the development of social technology and economy, the transformation of lifestyle and the deterioration of the environment, the spectrum of diseases in our country has changed. The number of chronic diseases such as diabetes, hypertension, and obesity has increased sharply, and the number of sub-healthy people is also increasing. At the same time, people's awareness of health care is becoming stronger and stronger, and the concept of medical treatment has changed from the type of after-treatment to the type of preventive care. People are paying more and more attention to the prevention of chronic diseases through a healthy lifestyle and dietary nutrition. [0003] Due to their remarkable physiological functions, functi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L33/00
CPCA23V2002/00A23V2250/21A23V2250/211A23V2250/2112A23V2250/213A23V2250/21168
Inventor 缪铭江波叶凡张涛张程孙家宝田雨晴
Owner JIANGNAN UNIV
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