Light and thermal controlled nano supermolecule vesicle as well as preparation method and application thereof
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A supramolecular and thermal regulation technology, applied in medical preparations containing active ingredients, microcapsules, nanocapsules, etc., can solve the problems of reducing the biocompatibility of materials, limiting practical application, unfavorable cost control, etc., and achieve a good response. high performance, simple preparation method and low dosage
Inactive Publication Date: 2015-04-01
NANKAI UNIV
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[0003] However, combining different response sites usually requires complex covalent synthesis, which is not only unfavorable for cost control, but also reduces the biocompatibility of materials, and also limits the possibility of further practical applications.
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[0026] A nano-supramolecular vesicle regulated by light and heat, whose construction unit is based on sulfonated calix[4]arene, and amphiphilic anthracene ether (AnPy) as the object, and constructs a supramolecular assembly through supramolecular interactions. The unit structure is as follows:
[0027]
[0028] The preparation method is as follows: respectively dissolving sulfonated calix[4]arene and amphiphilic anthracene ether in water, and uniformly mixing to obtain a light- and heat-regulated nano-supramolecular vesicle solution, in which the sulfonated nano-supramolecular vesicle solution The concentrations of calix[4]arene and amphiphilic anthracene were 0.04 mM and 0.10 mM, respectively.
[0029] Detection and analysis of the prepared nano-supramolecular vesicles:
[0030] 1) The particle size and morphology of the nanosupramolecular vesicles:
[0031] First, by measuring the light transmittance of the solution to determine the aggregation concentration ratio of th...
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Abstract
The invention relates to a light and thermal controlled nano supermolecule vesicle. In a construction unit of the light and thermal controlled nano supermolecule vesicle, sulphonated calyx arene is taken as a host, amphiphilic anthracene ether (AnPy) is taken as a guest, and a supramolecular assembly is constructed under the action of supermolecules. A preparation method of the light and thermal controlled nano supermolecule vesicle comprises the following steps: dissolving sulphonated calyx arene and amphiphilic anthracene ether in water respectively, and uniformly mixing to obtain light and thermal controlled nano supermolecule vesicle solution, wherein concentrations of sulphonated calyx arene and amphiphilic anthracene in the nano supermolecule vesicle solution are 0.04mM and 0.10mM respectively. The light and thermal controlled nano supermolecule vesicle has the advantages that the preparation method of the nano supermolecule vesicle is simple, and cost is low; the prepared supermolecule vesicle has good responsibility in a short time by means of external temperature and ultraviolet irradiation, and the supermolecule vesicle can be depolymerised by means of visible light irradiation after being mixed with a photodynamic therapy model drug Eosin Y, so that the light and thermal controlled nano supermolecule vesicle has a broad application prospect in the field of loading, transportation and controlled release of photodynamic therapy drugs.
Description
【Technical field】 [0001] The invention belongs to the technical field of nano-supramolecular materials, in particular to a nano-supramolecular vesicle regulated by light and heat and its preparation method and application. 【Background technique】 [0002] In recent years, multi-stimuli-responsive materials have been applied in many fields, including self-healing materials, microreactors, and nanocarriers (R.Savic, L.B.Luo, A.Eisenberg and D.Maysinger, Science, 2003, 300, 615–618). Common stimulation methods include: light, heat, magnetism, pH and redox, etc. Yuan, Z.N.Cai, Y.Xin, Y.Kang, Y.W.Yin, J.Am.Chem.Soc., 2010, 132, 9268–9270; (3) C.Peitsch, R.Hoogenboom, U.S.Schubert, Angew.Chem ., Int. Ed., 2009, 48, 5653–5656; (4) A. Napoli, M. Valentini, N. Tirelli, M. Müller, J.A. Hubbell, Nat. Mater., 2004, 3, 183–189). Among them, since light and heat do not need to add additional substances to the system, and are easy to operate and low in cost, the application of their respo...
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