Cooperative operation device for micro-nano operation robot and its operation method for microinjection

A collaborative operation and microinjection technology, applied in enzymology/microbiology devices, biochemical cleaning devices, biochemical equipment and methods, etc., can solve the problems of poor flexibility, easy removal from the microscope field of view, injection, etc., and achieve low cost , easily automated effects

Active Publication Date: 2016-06-15
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is: to effectively solve the problem that the operating end of the micro-nano operation robot system is easy to move out of the field of view of the microscope when the large-stroke rotation is performed, and the flexibility is poor, and the ordinary micro-nano operation robot cannot actively select a suitable angle when performing microinjection For the problem of injection, a micro-nano operation robot cooperative operation device and its operation method for microinjection are provided

Method used

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  • Cooperative operation device for micro-nano operation robot and its operation method for microinjection
  • Cooperative operation device for micro-nano operation robot and its operation method for microinjection
  • Cooperative operation device for micro-nano operation robot and its operation method for microinjection

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Embodiment 1

[0022] Embodiment 1, see attached figure 1 , a micro-nano operation robot cooperative operation device, which includes: a slow-speed high-precision micro-nano operation robot 9, a fast high-precision micro-nano operation robot 12 and a micro-manipulator 11; a slow-speed high-precision micro-nano operation robot 9, a fast high-precision micro-nano operation robot The bottoms of the nano-manipulator robot 12 and the micro-manipulator 11 are installed on the annular support track 1 through the mounting table 3;

[0023] See attached figure 2 , 3 , the inner ring of the annular support track 1 is a smooth surface, and the outer ring has a gear ring; one end of the mounting table 3 is provided with an elastic clamping mechanism 2, and the elastic clamping mechanism 2 is provided with an inner smooth guide wheel 7; The mounting table 3 on the opposite side of the mechanism 2 is provided with a driving motor 4, an external driving gear 5 and an external driven gear 6, and the exte...

Embodiment 2

[0027] Embodiment 2, the micro-nano operation robot cooperative operation device is used for the operation method of microinjection, it is based on the micro-nano operation robot cooperative operation device described in embodiment 1, and includes the following steps:

[0028] A. Adjust the center of the field of view of the microscope to coincide with the center of the annular support track 1, and adjust the slow-speed high-precision micro-nano manipulation robot 9 and the fast high-precision micro-nano manipulation robot 12 so that the micromanipulators 11 on them all point to the center of the field of view;

[0029] B. Operate the fast and high-precision micro-nano manipulating robot 12 used to fix the cells, fix the cell with the suction pipe on it to fix the probe 15 and move it to the center of the field of view, and then release the cell to control the fast and high-precision micro-nano manipulating robot 12 Lift the pipette fixed probe 15 to 50 μm in the vertical direc...

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Abstract

The invention relates to the technical field of micro-nano operation, and specifically to a cooperating device for a micro-nano operating robot and its injection operating method. The technical solution of the cooperating device for a micro-nano operating robot is that the bottoms of a low speed high-precision micro-nano operating robot, a fast speed high-precisioni micro-nano operating robot and a micromanipulator are mounted on a circular supporting rail through mounting tables. By arranging a circular guide rail, the device of the invention not only can realize 360-degree rotation of the operating terminal, but also can guarantee that the operating terminal is always in the visual range of a microscope, thereby easily realizing automation. The operating method of the invention can autonomously select the injection angle during microinjection, select the position on the outer wall of a cell closer to a cell nucleus position, and avoid difficulty for adjusting a cell position by traditional manual operation.

Description

technical field [0001] The invention relates to the field of nano-operation technology, in particular to a micro-nano operation robot cooperative operation device and an injection operation method thereof. Background technique [0002] Today, with the rapid development of micro-nano technology and robots, how to use robotics to realize complex and flexible operations under the microscope has become extremely important. In microinjection, analysis of single-cell mechanical properties, cell sorting, microstructure and assembly of micro-nano devices, bottom-up assembly of microbial structures for human organ regeneration, there is an urgent need for a device to achieve micro-nanoscale microscopic A complex and flexible automated cooperative operation device. [0003] At present, there are already some multi-degree-of-freedom single-micro-nano manipulation robot platforms, which have been widely used in fields such as microinjection and other single-cell manipulations. However...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B25J9/18C12M1/00
Inventor 黄强王化平刘晓明石青陈少奇福田敏男
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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