Method for extracting and separating diosmetin from water chestnut peel

A technology of diosmin and water chestnut skin, which is applied in the direction of organic chemistry, can solve unseen problems, achieve low production cost, good separation effect, and meet the needs of the pharmaceutical industry
CN104529976AInactive Publication Date: 2015-04-22HEZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HEZHOU UNIV
Publication Date
2015-04-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for extracting and separating diosmetin from a water chestnut peel and belongs to the field of natural organic chemistry. The method is characterized by comprising the following steps: extracting diosmetin from the water chestnut peel by taking an acetone water solution as an extraction solvent; extracting the extract by using ethyl acetate; performing chromatography separation on the extract by virtue of intermediate-pressure MCI and a polyamide column; repeatedly purifying by using Sephade x LH-20 gel chromatography to obtain a diosmetin product of which the content is larger than 95%. The method disclosed by the invention opens up a new way for extracting and separating the diosmetin from natural plants, and is good in separation effect, high in product purity and capable of changing the water chestnut peel which is always considered as waste into a valuable material; the used MCI resin, polyamide and gel can be reused; the raw materials are easily available; resources are sufficient; the production cost is low; large-scale production can be realized; the requirements of medical industry are satisfied.
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Description

technical field

[0001] The invention belongs to the field of natural organic chemistry, and relates to a method for extracting and separating diosmin, in particular to a method for extracting and separating diosmin from water chestnut skin. Background technique

[0002] Diosmertin, whose chemical name is 4′-methoxy-5,7,3′-trihydroxyflavone, is a yellow needle-like crystal and is a natural flavonoid compound, mainly found in Labiatae plants In various plants such as mint, lemon, white thorn flower, Mongolian radish, velvet salvia, dandelion and so on. Modern studies have shown that diosmin has anti-oxidation, anti-infection, anti-shock, anti-mutagenic and anti-allergic properties and inhibits carcinogenesis. It can be used as an antiviral drug for the treatment of HIV and other viral infections, and can also treat various kind of inflammation.

[0003] Derynodin can be isolated from plants, mainly through ethanol extraction, extraction, chromatography, chromatography, cryst...

Claims

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