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Pharmaceutical composition for treating leukocytopenia and immune hypofunction caused by radiotherapy and chemotherapy and preparation method of oral granules of pharmaceutical composition

A technology for leukopenia and immune function, applied in the field of medicine, can solve the problems of poor curative effect, backward dosage form, poor targeting, etc., and achieve the effect of ideal therapeutic effect

Inactive Publication Date: 2015-04-29
张煜萱 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are many Chinese patent medicines for the treatment of this disease, their curative effect is not good enough, their dosage forms are backward, and their pertinence is also relatively poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] An oral granule of a pharmaceutical composition for treating leukopenia and immunosuppression caused by radiotherapy and chemotherapy. The parts by weight of the raw materials are: 20 parts of sealwort; 5 parts of ginseng; 5 parts of Hericium erinaceus, 10 parts of raspberry; 10 parts of angelica; 10 parts of Burnet; parts; 10 parts of tangerine peel.

[0019] The preparation method of the oral granules of a pharmaceutical composition for treating leukopenia and immunosuppression caused by radiotherapy and chemotherapy is as follows:

[0020] (1) First, mix and pulverize 20 parts of sealwort, 5 parts of Hericium erinaceus, 10 parts of angelica, 10 parts of Ligustrum lucidum, 10 parts of peanut clothes, and 10 parts of tangerine peel, and then add the same volume of the above components. Ethanol solution, and the concentration of ethanol is 85%, carry out reflux extraction after 2 hours, filter it, keep the filtrate, and add 6 times of the same amount of concentration o...

Embodiment 2

[0029] The oral granule prepared in Example 1 was used to administer ICR mice with a body weight of 20-25 G, half male and half male.

[0030] After pre-testing, the oral granule prepared in Example 1 has extremely low toxicity, and LD50 cannot be detected, so the maximum daily dose was determined for Kunming mice. Maximum dosage is 0.75 / kg * 25g * 30 (multiple)=0.56g / every day, is 30 times of adult's clinical oral electuary dose, observes after 7 days without a case of poisoning death, all healthy survival, proves thus the present invention The oral granule made from the composition has no toxic and side effects.

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Abstract

The invention discloses a pharmaceutical composition for treating leukocytopenia and immune hypofunction caused by radiotherapy and chemotherapy and a preparation method of oral granules of the pharmaceutical composition. The pharmaceutical composition is characterized in that the pharmaceutical composition comprises the following raw materials in parts by weight: 20 parts of rhizoma polygonati, 5 parts of ginseng, 5 parts of hericium erinaceus, 10 parts of palmleaf raspberry fruits, 10 parts of angelica sinensis, 10 parts of sanguisorba officinalis, 10 parts of fructus ligustri lucidi, 10 parts of jujube, 10 parts of peanut coats and 10 parts of pericarpium citri reticulatae. Systematic observations on clinical and scientific research cases show that the pharmaceutical composition has the effects of replenishing qi to invigorate the spleen, nourishing yin and enriching essence, enriching the blood and invigorating the circulation of blood, and has an ideal therapeutic effect on both qi-yin deficiency type leukocytopenia and immune hypofunction caused by radiotherapy and chemotherapy.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating leukopenia and immunosuppression caused by radiotherapy and chemotherapy, in particular to a Chinese herbal medicine composition for treating leukopenia and immunosuppression caused by radiotherapy and chemotherapy, and belongs to the technical field of medicine. Background technique [0002] Cancer is a malignant disease that seriously threatens human health. In addition to surgical treatment for early detection, radiotherapy and chemical drug treatment are still effective and important treatments for this disease. And this treatment method is "no distinction between the enemy and the enemy", which not only kills tumor cells, but also kills normal cells, especially leukocytes severely, so that the leukocytes and immune function of patients undergoing radiotherapy and chemotherapy are reduced, which seriously affects the progress of radiotherapy and chemotherapy, and even causes radiothe...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/16A61P7/00A61P37/04
CPCA61K9/1652A61K36/06A61K36/232A61K36/258A61K36/48A61K36/638A61K36/725A61K36/73A61K36/739A61K36/752A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 张煜萱崔博
Owner 张煜萱
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