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Application of recombinant human endostatin in preparing drugs for treating ocular neovascular diseases

A technology of vascular endothelium and new blood vessels, applied in the field of biopharmaceuticals, can solve the problems of multiple treatments, failure to improve vision, and high price

Inactive Publication Date: 2015-04-29
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both laser and surgery can only be carried out locally. The long-term application of hormones will bring a series of side effects. Photodynamic therapy and vascular factor antagonists are expensive and often require multiple treatments. They cannot reverse the lesions that have occurred, and cannot produce long-term vision improvement

Method used

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  • Application of recombinant human endostatin in preparing drugs for treating ocular neovascular diseases
  • Application of recombinant human endostatin in preparing drugs for treating ocular neovascular diseases

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Embodiment Construction

[0013] In order to better illustrate the present invention, the following combines drug experiments, animal experiments and clinical experiments to illustrate its use in the preparation of ocular surface anti-angiovascular drugs. If there is no special description, the experimental materials involved in the following can be commercially available. get.

[0014] 1. Effect of recombinant human endostatin injection (Endostar) on the proliferation of vascular endothelial cells

[0015] 1.1 Experimental materials

[0016] Cells: Human umbilical vein endothelial cell line ECV304 was provided by the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0017] Main biochemical reagents: Recombinant Human Endostatin Injection (Endostar), produced by Shandong Xiansheng Maidejin Biopharmaceutical Co., Ltd.

[0018] 1.2 Experimental method

[0019] The human umbilical vein endothelial cell line ECV304 was resuscitated, cultured, passaged and identified, and the cells in the logarith...

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Abstract

The invention discloses the application of recombinant human endostatin in preparing drugs for treating ocular neovascular diseases. Researches show that the recombinant human endostatin can remarkably inhibit the formation of ocular neovasculars, is safe, non-toxic and free of drug resistance, and has wide application prospects in preparing drugs for treating ocular neovascular diseases.

Description

Technical field: [0001] The invention belongs to the technical field of biopharmaceuticals, and specifically relates to the application of recombinant human endostatin in the preparation of drugs for treating ocular surface neovascular diseases. technical background: [0002] The common name of Endostar is recombinant human vascular endostatin injection, which is a new type of recombinant human vascular endothelial inhibitory drug independently developed by Chinese scholars. Endostar is produced by recombinant DNA technology, using Escherichia coli as a protein expression system. recombinant human endostatin. The mechanism of action of Endostar is to inhibit tumor angiogenesis, block the nutrient supply of tumor cells, and finally achieve the purpose of "starving" tumor cells. Endostar is a national first-class new drug, which does not belong to chemotherapy drugs. The tumor grows up to 2mm in the body 3 When above, it is necessary to form its own vascular network to trans...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P27/02A61P9/10
Inventor 沈婷洪朝阳
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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