Chemiluminescent quantitative determination kit for pepsinogen II and preparation method of chemiluminescent quantitative determination kit

A quantitative detection technology for pepsinogen, applied in pepsinogen Ⅱ chemiluminescent quantitative detection kit and its preparation field, can solve the problem of no correlation of gastric acid secretion and achieve high sensitivity
CN104569415AInactive Publication Date: 2015-04-29HENAN MAINCARE BIOLOGICAL TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HENAN MAINCARE BIOLOGICAL TECH
Publication Date
2015-04-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of immunodetection, in particular to a chemiluminescent quantitative determination kit for pepsinogen II and a preparation method of the chemiluminescent quantitative determination kit. The chemiluminescent quantitative determination kit for the pepsinogen II comprises (1) a pepsinogen II antibody coated micropore plate, (2) an HRP-labeled pepsinogen II antibody, (3) series pepsinogen II calibration materials diluted by a calibration material diluent, (4) a luminescent substrate A, (5) a luminescent substrate B and (6) a solid washing liquid. The kit disclosed by the invention is capable of detecting the content of the pepsinogen II in serum; and the level of the pepsinogen II in the serum is in positively relevant to atrophic gastritis and peptic ulcer; in treatment of peptic ulcer, the treatment result can be judged by monitoring the change of the degermed pepsinogen; and the chemiluminescent quantitative determination kit is noninvasive, simple and fast in detection method, high in sensitivity, wide in detection range and the like.
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Description

technical field

[0001] The invention relates to the field of immune detection, in particular to a pepsinogen II chemiluminescence quantitative detection kit and a preparation method thereof. Background technique

[0002] Pepsinogen (PG) is a digestive enzyme precursor secreted by the stomach and an inactive precursor of pepsin in gastric juice. It is a protein polypeptide chain composed of 375 amino acids with an average molecular weight of 42,000. There are seven groups of pepsin isoenzymes in the gastric mucosa. PG is synthesized on ribosomes, secreted out of cells by Golgi apparatus, and becomes pepsin after being activated by hydrochloric acid. According to biochemical properties, immunogenicity, cell source and tissue distribution, it can be divided into two subgroups, PGⅠ and PGⅡ, of which 6~7 components have similar immunogenicity and are called PGⅡ. In addition to the secretion of the principal cells of the gland, the mucous neck cells of the oxyntic glands, the mu...

Claims

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