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A pharmaceutical composition containing cetylpyridinium chloride

A technology of cetylpyridinium chloride and composition, which is applied in the field of pharmaceutical preparations, can solve the problems of few manufacturers, inconvenient carrying, and large volume of gargle

Inactive Publication Date: 2015-05-06
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, cetylpyridinium chloride preparations on the market in China are mainly gargles. Because gargles are generally large in size and inconvenient to carry, there are also cetylpyridinium chloride solid preparations on the market in China, but there are few manufacturers, and only two tablets are on the market. The main reason is that cetylpyridinium chloride solid preparations need to solve some technical difficulties in order to ensure that the cetylpyridinium chloride solid preparations meet the requirements of patient compliance and product quality stability in clinical application

Method used

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  • A pharmaceutical composition containing cetylpyridinium chloride
  • A pharmaceutical composition containing cetylpyridinium chloride
  • A pharmaceutical composition containing cetylpyridinium chloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] prescription:

[0013]

[0014] Preparation Process:

[0015] 1. Particle size requirements of raw and auxiliary materials: the particle size of sucrose is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0016] 2. Weigh the prescribed amount of cetylpyridinium chloride, sucrose, hydroxypropyl cellulose, xanthan gum, tartrazine aluminum lake and mix evenly, use 5% PVPK30 aqueous solution as binder to granulate, and dry at 60°C for 1 hour , passed through a 14-mesh sieve for granulation, added menthol and magnesium stearate, mixed evenly, compressed into tablets, and packaged.

Embodiment 2

[0018] prescription:

[0019]

[0020] Preparation Process:

[0021] 1. Particle size requirements of raw and auxiliary materials: the particle size of lactose is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0022] 2. Take the cetylpyridinium chloride, lactose, hydroxypropyl cellulose, xanthan gum, tartrazine aluminum lake and mix evenly, use the starch slurry as the binder to granulate, dry at 60°C for 1.5 hours, pass Sieve through a 14-mesh sieve, add menthol and magnesium stearate, mix evenly, compress into tablets, and pack.

Embodiment 3

[0024] prescription:

[0025]

[0026] Preparation Process:

[0027] 1. Particle size requirements of raw and auxiliary materials: the particle size of mannitol is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0028] 2. Weigh the prescribed amount of cetylpyridinium chloride, mannitol, crospovidone, carbomer 934, tartrazine aluminum lake and mix evenly, use 5% PVPK30 aqueous solution as the binder to granulate, under the condition of 60 ℃ Dry for 1.5 hours, pass through a 14-mesh sieve for granulation, add menthol and silicon dioxide, mix evenly, compress into tablets, and pack.

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Abstract

A pharmaceutical composition containing cetylpyridinium chloride is provided. The composition is characterized in that: in each 1000 preparation units, the composition comprises 1.5-2.5 g of cetylpyridinium chloride, 350-700 g of a filler, 20-80 g of a disintegrating agent, 0.5-5 g of a thickening agent, 0.01-0.1 g of a coloring agent, 0.05-0.5 g of a corrigent, 5-50 g of an adhesive and 1-5 g of a lubricating agent; and both taste and quality of the composition meet requirements.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, relates to a composition for oral care and treatment, in particular to a pharmaceutical composition containing cetylpyridinium chloride. Background technique [0002] Cetylpyridinium chloride is a cationic quaternary ammonium compound. As a surfactant, it inhibits and kills bacteria mainly by reducing surface tension. In vitro test results show that this product has inhibitory and killing effects on a variety of oral pathogenic and non-pathogenic bacteria, including Candida albicans. After gargling, it can reduce or inhibit the formation of dental plaque, and has the effect of keeping the mouth clean and removing bad breath. [0003] At present, cetylpyridinium chloride preparations on the market in China are mainly gargles. Because gargles are generally large in size and inconvenient to carry, there are also cetylpyridinium chloride solid preparations on the market in China, but there...

Claims

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Application Information

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IPC IPC(8): A61K31/44A61K9/20A61K47/38A61K47/32A61P1/02A61P31/02
Inventor 王国华刘萍胡延贵罗成文
Owner 四川健能制药有限公司
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