A pharmaceutical composition containing cetylpyridinium chloride

A technology of cetylpyridinium chloride and composition, which is applied in the field of pharmaceutical preparations, can solve the problems of few manufacturers, inconvenient carrying, and large volume of gargle

Inactive Publication Date: 2015-05-06

四川健能制药有限公司

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AI-Extracted Technical Summary

Problems solved by technology

[0003] At present, cetylpyridinium chloride preparations on the market in China are mainly gargles. Because gargles are generally large in size and inconvenient to carry, there are also cetylpyridinium chloride solid preparations on the market in China, but there are few manufacturers, and only two tab...

Abstract

A pharmaceutical composition containing cetylpyridinium chloride is provided. The composition is characterized in that: in each 1000 preparation units, the composition comprises 1.5-2.5 g of cetylpyridinium chloride, 350-700 g of a filler, 20-80 g of a disintegrating agent, 0.5-5 g of a thickening agent, 0.01-0.1 g of a coloring agent, 0.05-0.5 g of a corrigent, 5-50 g of an adhesive and 1-5 g of a lubricating agent; and both taste and quality of the composition meet requirements.

Application Domain

AntisepticsDigestive system +3

Technology Topic

ChemistryAdhesive +4

Image

Examples

Experimental program(3)
Effect test(1)

Example Embodiment

[0011] Example 1

[0012] prescription:

[0013]

[0014] Preparation Process:

[0015] 1. Particle size requirements of raw and auxiliary materials: the particle size of sucrose is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0016] 2. Weigh the prescribed amount of cetylpyridinium chloride, sucrose, hydroxypropyl cellulose, xanthan gum, tartrazine aluminum lake and mix evenly, use 5% PVPK30 aqueous solution as binder to granulate, and dry at 60°C for 1 hour , passed through a 14-mesh sieve for granulation, added menthol and magnesium stearate, mixed evenly, compressed into tablets, and packaged.

Example Embodiment

[0017] Example 2

[0018] prescription:

[0019]

[0020] Preparation Process:

[0021] 1. Particle size requirements of raw and auxiliary materials: the particle size of lactose is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0022] 2. Take the cetylpyridinium chloride, lactose, hydroxypropyl cellulose, xanthan gum, tartrazine aluminum lake and mix evenly, use the starch slurry as the binder to granulate, dry at 60°C for 1.5 hours, pass Sieve through a 14-mesh sieve, add menthol and magnesium stearate, mix evenly, compress into tablets, and pack.

Example Embodiment

[0023] Example 3

[0024] prescription:

[0025]

[0026] Preparation Process:

[0027] 1. Particle size requirements of raw and auxiliary materials: the particle size of mannitol is less than 250 microns, and the particle size of menthol is less than 150 microns;

[0028] 2. Weigh the prescribed amount of cetylpyridinium chloride, mannitol, crospovidone, carbomer 934, tartrazine aluminum lake and mix evenly, use 5% PVPK30 aqueous solution as the binder to granulate, under the condition of 60 ℃ Dry for 1.5 hours, pass through a 14-mesh sieve for granulation, add menthol and silicon dioxide, mix evenly, compress into tablets, and pack.

PUM

Property	Measurement	Unit
Particle size	<= 250.0	µm
Particle size	<= 150.0	µm
Particle size	<= 300.0	µm

Description & Claims & Application Information

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