Method for detecting content of moroxydine hydrochloride in Ganmaoqing capsule

Abstract

The invention discloses a method for detecting the content of moroxydine hydrochloride in a Ganmaoqing capsule. According to the invention, the determination is performed by adopting reversed-phase high-performance liquid chromatography, using the moroxydine hydrochloride as a contrast, using octadecyl silane bonded silica gel as a filling agent and using triethylamine-acetonitrile with a volume ratio of 80-20 as a mobile phase, wherein a pH value of triethylamine is regulated to 3.0 by using phosphoric acid. The method has the advantages of strong specificity, good precision and repeatability, strong linear preserving property and stability, and the like, and can be used for effectively detecting the content of moroxydine hydrochloride in the Ganmaoqing capsule so as to control the quality of a product and ensure the safety and effectiveness of a medicine preparation.

Description

technical field [0001] The invention relates to a method for detecting the content of active ingredients in pharmaceutical preparations, in particular to a method for detecting the content of morpholine guanidine hydrochloride in traditional Chinese medicine capsule preparations for treating colds, and belongs to the technical field of drug quality control. Background technique [0002] Ganmaoqing Capsule is a traditional Chinese medicine capsule preparation for the treatment of colds. It has the effects of dispelling wind, relieving the exterior, clearing away heat and detoxifying. The prescription is composed of 6 traditional Chinese medicines such as Nanlangen and Daqingye, and three chemical medicines: acetaminophen, morpholine hydrochloride, and chlorpheniramine maleate. The specific preparation methods and uses have been recorded in the revision of national drug standards. The quality standard attached to the approval document (2002ZFB0245). The morpholine hydrochlori...

AI Technical Summary

Problems solved by technology

The current quality standard of Ganmaoqing Capsules only stipulates the content determination of acetaminophen, but does not stipulate the content determination of morpholine hydrochloride

And although there are some relevant bibliographical reports about the content detection method of morpholine guanidine hydrochloride, such as HPLC method simultaneously measures the content of three components in Ganmaoqing Capsules, high performance liquid chromatography simultaneously measures the content of two components in Ganmaoqing Capsules, etc., Including the Chinese invention patent application with the publication number CN103091443A, which discloses a "method for detecting the content of morpholine guanidine hydrochloride and copper acetate in mixed preparations", etc., the mobile phases used include sodium acetate-acetic acid, methanol-water-glacial acetic acid etc., but the resolution of these detection methods is not ideal, which affects the accuracy of the analysis results, and has not been included in the national standard

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