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A pharmaceutical composition for preventing and treating cerebral ischemia

A technology of cerebral ischemia and aspirin, which is applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve the problems such as the effect is not very significant

Active Publication Date: 2017-01-11
TIANJIN GOALGEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The use of aspirin in the treatment of cerebral ischemia has been recorded in the prior art, but the pharmacological effects show that the effect is not very significant when used in low doses (75-100mg / kg)

Method used

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  • A pharmaceutical composition for preventing and treating cerebral ischemia
  • A pharmaceutical composition for preventing and treating cerebral ischemia
  • A pharmaceutical composition for preventing and treating cerebral ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 5g of aspirin, add 600ml of water for injection, heat to 60°C and dissolve to obtain aspirin solution; cool to room temperature, add 5g of cysteine ​​hydrochloride, 10g of sodium bisulfite, and 0.1mol of phosphate buffer; stir to dissolve; add to the solution Activated carbon with a total volume of 0.01%, stirred and adsorbed for 14 minutes, filtered for decarbonization; added rhEGF 10g to the filtrate, added water for injection to 1000ml, potted and sterilized to obtain the finished product.

Embodiment 2

[0018] Take 10g of aspirin, add 600ml of water for injection, heat to 60°C and dissolve to obtain aspirin solution; cool to room temperature, add 5g of cysteine ​​hydrochloride, 10g of vitamin C, and 0.1mol of phosphate buffer; stir to dissolve; add the total volume of 0.01% activated carbon, stirred and adsorbed for 14 minutes, filtered and decarbonized; added rhEGF 20g to the filtrate, added water for injection to 1000ml, potted and sterilized to obtain the finished product.

Embodiment 3

[0020] Take 2 g of aspirin, add 600 ml of water for injection, heat to 60 ° C to dissolve, and obtain aspirin solution; cool to room temperature, add 5 g of cysteine ​​hydrochloride, 10 g of glutathione, and 0.1 mol of phosphate buffer; stir to dissolve; add to the solution Activated carbon with a total volume of 0.01%, stirred and adsorbed for 14 minutes, filtered for decarbonization; added rhEGF 4g to the filtrate, added water for injection to 1000ml, potted, and sterilized to obtain the finished product.

[0021] 1 Experimental materials

[0022] 1.1 Animals and grouping

[0023] 150 SD rats, half male and half male, weighing 220-300 g, were provided by the Academy of Military Medical Sciences of the Chinese People's Liberation Army. After one week of adaptive feeding, they were randomly divided into 6 groups, namely

[0024]

[0025] 2 Test method

[0026] 2.1 Modeling

[0027] According to the Zea-Longa suture method, the blood supply to the right MCA was blocked. ...

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Abstract

The invention discloses injection for preventing and treating cerebral ischemia. The injection comprises rhEGF (Recombinant Human Epidermal Growth Factor), aspirin, an antioxidant, a cosolvent and a pH regulator. The pharmacological research shows that the medicine can pass through blood brain barrier to be mainly distributed in cerebral hemisphere, brainstem and the like, takes spasmolysis effect on vascular smooth muscle, and can expand small vessels, reduce resistance of blood vessels of brain, increase cerebral blood flow, protect endothelial cells and improve micro-circulation. The injection has the functions of increasing cerebral perfusion of distant sites after MCAO (middle cerebral artery occlusion), resisting apoptosis, protecting nerve cells in the distant sites, and reducing the diaschisis damage to brain tissues in the distant sites due to interruption of conduction paths of nerve fibers; therefore, the injection has the effect of reducing the disordered brain function in the distant sites and has a certain effect in clinical prognosis after relieving stroke.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating brain diseases, in particular to a pharmaceutical composition for preventing and treating cerebral ischemia. Background technique [0002] Cerebrovascular disease is one of the main diseases that seriously endanger human life and health in the world today, and it is a common and frequently-occurring disease in our country. Cerebral ischemia is a kind of cerebrovascular accident. It is a common disease and frequently-occurring disease among middle-aged and elderly people, and it seriously threatens human health and life. In recent years, with the continuous development of science and technology, researchers have conducted in-depth studies on the pathogenesis of cerebral ischemia and the cascade reaction of brain tissue cell damage, and found that it can inhibit apoptosis, reduce inflammation and free radicals, etc. However, many neuroprotective agents designed and manufac...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P9/10A61K31/616
Inventor 梁青梁兰邹庆薇郝瑞雪闻家兴王菁于琪顾久莹田雪李姣刘建强
Owner TIANJIN GOALGEN BIOTECH
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