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Application of chlorogenic acid in preparation of medicines for treating lupus erythematosus

一种红斑狼疮、绿原酸的技术，应用在药物组合、医药配方、杂环化合物有效成分等方向，能够解决中药复方成分复杂、作用机理不明确、药效成分不确切等问题，达到改善机体免疫机能的效果

Inactive Publication Date: 2015-05-27
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of traditional Chinese medicine compound is complex, its active ingredients are not exact, and its mechanism of action is not clear, so there are certain safety hazards

Method used

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  • Application of chlorogenic acid in preparation of medicines for treating lupus erythematosus
  • Application of chlorogenic acid in preparation of medicines for treating lupus erythematosus
  • Application of chlorogenic acid in preparation of medicines for treating lupus erythematosus

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0035] Example 1: In vivo pharmacodynamics study of chlorogenic acid in treating lupus erythematosus

[0036] 1. Materials and methods

[0037] 1.1 Animals

[0038] BALB / c mice, weighing 17.0-21.0 g, 5-7 weeks old, half male and half male, were provided by the Experimental Animal Center of Sichuan University.

[0039] drug

[0040] Chlorogenic acid, prepared by Sichuan Jiuzhang Biotechnology Co., Ltd., with a content of 99.2%. Batch number: 131101. During the experiment, physiological saline was used to prepare three concentrations of high, medium and low concentrations for use. Prednisone, produced by Zhejiang Xianju Pharmaceutical Co., Ltd., 5 mg / tablet, batch number: 110502; Escherichia coli lipopolysaccharide, produced by sigma Company, Lot58kp8725, prepared with normal saline before use to 0.25 g / L for later use. HEP-2 cell sheets produced by Scimedx. Fluorescein-labeled goat anti-mouse serum (FITC Goat Anti-Mouse IgG), Vector company. ENA polypeptide immunoblottin...

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Abstract

The invention discloses an application of chlorogenic acid in preparation of medicines for treating lupus erythematosus. According to the application, the immune function is improved through the chlorogenic acid, so that the target of treating the lupus erythematosus is reached. The invention further discloses a preparation for treating lupus erythematosus; and the preparation comprises the chlorogenic acid and a pharmaceutically acceptable excipient or auxiliary material. The invention further discloses a combined medicine for treating the lupus erythematosus. The combined medicine comprises the chlorogenic acid and medicines for treating lupus erythematosus.

Description

technical field [0001] The invention relates to the use of chlorogenic acid in the preparation of medicines for treating lupus erythematosus, belonging to the field of medicines. Background technique [0002] Chlorogenic acid (CGA), also known as coffee tannic acid, chemically named 3-0-caffeoylquinic acid (3-0-caffeoylquinic acid), is composed of caffeic acid (Caffeic acid) and quinic acid (Quinic acid) composed of carboxyphenolic acid. [0003] Chlorogenic acid is a product of aerobic respiration metabolism in plants, and is the main active ingredient in many Chinese medicinal materials and fruits and vegetables. It has a variety of biological activities, such as: cardiovascular protection, anti-oxidation, anti-ultraviolet and anti-radiation, Antimutagenic and anticancer effects, antibacterial effects, antiviral effects, lipid-lowering and hypoglycemic effects, immune regulation effects, etc. It has a wide range of applications in the fields of medicine, chemical industr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P37/02
CPCA61K31/429A61K31/4706A61K31/498A61K31/519A61K31/52A61K38/2292A61K31/216A61K45/06A61P37/02A61K2300/00
Inventor 张洁贾静黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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