Vaccine for preventing porcine epizootic diarrhea

A porcine epidemic diarrhea and vaccine technology, applied in the field of genetic engineering, can solve the problems of long antigen gene, difficult to guarantee safety, poor strain stability, etc., and achieve the effect of good stability, good protection and good safety
CN104667296AInactive Publication Date: 2015-06-03SICHUAN AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN AGRI UNIV
Publication Date
2015-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of a recombinant salmonella having a nucleotide sequence as shown in SEQ ID NO: 1 in preparation of a medicine for preventing porcine epizootic diarrhea, and also discloses a vaccine which is prepared from the recombinant salmonella having the nucleotide sequence as shown in SEQ ID NO: 1 and pharmaceutically acceptable auxiliary materials or carriers and is used for preventing the porcine epizootic diarrhea. The specific antibody level of the vaccine disclosed by the invention for porcine epidemic diarrhea virus is high, so that the vaccine has a good protection effect on the porcine epizootic diarrhea disease; and the vaccine is good in clinical application prospect.
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Description

technical field

[0001] The invention relates to the field of genetic engineering, in particular to a vaccine for preventing porcine epidemic diarrhea disease. Background technique

[0002] Porcine epidemic diarrhea virus is the causative agent of porcine epidemic diarrhea disease (Porcine epidemic diarrhea, PED). There are yellow curds. PEDV is mainly transmitted through the fecal-oral route. After the piglets in the farrowing house ingest the virus through the digestive tract, the virus mainly invades the epithelial cells of the small intestinal mucosa in the jejunum and ileum, and begins to replicate. The infection of PEDV leads to the decrease of the activity of disaccharidase (lactase, sucrase, maltase), aminopeptidase and alkaline phosphatase on the surface of epithelial cell membrane; at the same time, the normal structure of intestinal villi epithelial cells is destroyed and cell fragmentation occurs, resulting in intestinal The atrophy of the villi and the reductio...

Claims

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