Graphene/ chitosan compound micro-capsule and preparation method thereof

A technology of chitosan microcapsules and composite microcapsules is applied in the directions of microcapsules, capsule delivery, pharmaceutical formulations, etc., to achieve the effects of simple operation, mild conditions and high reproducibility

Inactive Publication Date: 2015-06-10
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, graphene and chitosan composite materials have been widely studied as electrode modification materials, but there is no research report on the use of graphene to improve the mechanical properties of the membrane wall of chitosan microcapsules.

Method used

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  • Graphene/ chitosan compound micro-capsule and preparation method thereof
  • Graphene/ chitosan compound micro-capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] What this embodiment provides is a kind of in-situ introduction of graphene into the membrane wall of chitosan microcapsules, thus forming spherical graphene / chitosan composite microcapsules, with a size of 300-1000 μm and a particle size distribution Coefficient ≤ 6%.

[0030] Graphene is introduced into the membrane wall of the microcapsule, and the graphene effectively enhances the mechanical properties of the membrane wall of the composite microcapsule, and can regulate the release rate of the composite microcapsule to the loaded drug.

Embodiment 2

[0032] The preparation method of the composite microcapsules provided in this example first modifies graphene with chitosan quaternary ammonium salt to ensure that graphene can be stably dispersed in chitosan solution, and then based on the gas-liquid shearing effect in a self-made microfluidic device The mixed micro-droplets of graphene / chitosan are formed in the medium, and then dropped into the anionic surfactant solution, and the re-coagulation effect makes the graphene modified by chitosan quaternary ammonium salt and chitosan molecules precipitate together to form microcapsules Membrane wall, thereby obtaining graphene / chitosan composite microcapsules, graphene is introduced into the microcapsule membrane wall in situ.

[0033] Specific steps are as follows:

[0034] (1) prepare chitosan quaternary ammonium salt modified graphene:

[0035] Place the flask filled with 46ml of concentrated sulfuric acid (98%) in an ice-water bath and cool it to 0°C, take 2.0g of natural f...

Embodiment 3

[0041] Chitosan quaternary ammonium salt-modified graphene was prepared according to the steps in step (2) of Example 2, using the self-made microfluidic device in step (2) of Example 1. Add 2 g of chitosan to 10 mL of 0.2 mol / L acetic acid solution, stir at room temperature for 2 h to fully dissolve the chitosan, and let stand for 1 h after stirring to eliminate bubbles in the solution. The graphene modified by 5g chitosan quaternary ammonium salt is dispersed in 10mL water, then chitosan solution and modified graphene dispersion are mixed in a volume ratio of 10:2, then the mixed dispersion is controlled by a micro-injection pump to The flow rate of 3mL / h is passed into the circular capillary of the microfluidic device, N 2 As the external phase fluid, the gas is passed into the gap between the circular and square capillaries at a flow rate of 0.5 L / min. Under the action of gas shear, the mixed dispersion liquid forms micro-droplets at the outlet of the microfluidic device, ...

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Abstract

The invention relates to a graphene/ chitosan compound micro-capsule and preparation method thereof. The compound micro-capsule is regular in shape and uniform in granularity distribution; the mechanical performance of film wall is obviously improved; the compound micro-capsule is formed by in-situ introducing graphene into the film wall of a chitosan micro-capsule, wherein the compound micro-capsule is spherical and 300 to 1000 microns in size, and the granularity distribution coefficient is not greater than 6%. The preparation method of the compound micro-capsule comprises the steps of modifying graphene through chitosan quaternary ammonium salt to ensure that graphene can be stably dispersed in a chitosan solution; generating mixed micro drops of graphene/ chitosan in an independent micro-flow control device based on the air-liquid shearing effect; dropping into an anionic surfactant solution; performing compound flocculation to synchronously separate out chitosan quaternary ammonium salt modified graphene and chitosan to form micro-capsule film wall so as to obtain the graphene/ chitosan compound micro-capsule; graphene is in-situ introduced into the film wall of the micro-capsule. The method is simple to operate, mild in condition, and high in reproducibility.

Description

technical field [0001] The invention relates to nanoparticle / natural polymer composite microcapsules, in particular to introducing graphene into the membrane wall of the microcapsules through in-situ composite technology when gas-liquid microfluidic technology is used to prepare chitosan microcapsules to obtain an application Monodisperse graphene / chitosan composite microcapsules for drug controlled release and preparation method thereof. Background technique [0002] Chitosan (CS) is a natural polymer substance with biodegradability, biocompatibility, and biological non-toxicity. Chitosan-based microspheres or microcapsules have attracted more and more attention from scientists. And extensive research, and is widely used in the fields of cell embedding, enzyme immobilization, drug controlled release and so on. The commonly used methods for preparing chitosan microcapsules include emulsification-crosslinking method, emulsification-solvent evaporation method, spray drying me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36A61K47/04
Inventor 陈艳军赵子晗薛武子陈浩夏元玲何世文张柯王慧萍
Owner WUHAN UNIV OF TECH
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