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Rhubarb charcoal temperature-sensitive gel as well as preparation method and application thereof

A technology of thermosensitive gel and rhubarb charcoal, which is applied in the field of biopharmaceuticals and can solve problems such as no report on thermosensitive gel of rhubarb charcoal

Active Publication Date: 2015-06-10
武汉市第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there is no report on the rhubarb charcoal thermosensitive gel with poloxamer as the main matrix

Method used

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  • Rhubarb charcoal temperature-sensitive gel as well as preparation method and application thereof
  • Rhubarb charcoal temperature-sensitive gel as well as preparation method and application thereof
  • Rhubarb charcoal temperature-sensitive gel as well as preparation method and application thereof

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experiment example

[0033] 1. Instruments and materials

[0034] BP211D electronic balance (Germany sartorius); electronic balance (accurate to 0.01); thermometer (accurate to 0.1°C German testo); water bath; magnetic stirrer.

[0035] P407 is Poloxamer 407 (Poloxamer 407, Pluronic 1F127, F127, BASF, Germany), P188 is Poloxamer 188 (Poloxamer 188, Pluronic 1F68, F68, BASF, Germany); micron rhubarb carbon (batch number 130515, 130520, 130605); sodium benzoate and ethyl paraben are used for medicine, water is purified water, and other reagents are of analytical grade.

[0036] 2. Methods and results

[0037] 2.1 Evaluation indicators and operation methods

[0038] 2.1.1 Evaluation indicators

[0039] Phase transition temperature is the primary characteristic of thermosensitive gels. Whether the gel can gel at the medication site within a suitable time is directly related to the patient compliance and therapeutic effect of the preparation. Therefore, the prescription screening in this study uses...

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Abstract

The invention discloses a rhubarb charcoal temperature-sensitive gel, as well as a preparation method and application thereof. The rhubarb charcoal temperature-sensitive gel comprises rhubarb charcoal, P407 and P188; the granularity of the rhubarb charcoal is 15-45 mu m. The rhubarb charcoal temperature-sensitive gel is liquid when refrigerated in a fridge; when the gel is delivered to the gastric mucosa, the gel becomes a solid at the temperature of 35 DEG C because the P407 and the P188 are temperature-sensitive materials. The double effects of the physical hemostasis and the medicine hemostasis can be played when the gel reaches the surface of the gastric mucosa, so that the bleeding can be rapidly stopped.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals. Specifically, the invention relates to a rhubarb charcoal temperature-sensitive gel and a preparation method and application thereof. Background technique [0002] As a new dosage form, thermosensitive gel has the advantages of both solution and common gel. Protective effect and high patient compliance. [0003] Poloxamer is a typical temperature-sensitive polymer material, which has been recorded in many pharmacopoeias because of its good biocompatibility, and has been widely used in the field of pharmacy. Gel phase transition temperature is the primary characteristic of thermosensitive gels. Whether gelation can occur at the medication site within a suitable time is directly related to the patient compliance and therapeutic effect of the preparation. [0004] However, there is no report on the rhubarb charcoal thermosensitive gel with poloxamer as the main matrix. Contents of the...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/06A61P7/04A61P1/04
Inventor 时昭红张书
Owner 武汉市第一医院
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