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A kind of improved polarization liquid and its preparation method and application

A polarizing solution and potassium chloride technology, applied in the field of medicine, can solve the problems of diabetes and insulin resistance patients with poor results and blood sugar level fluctuations, achieve good liver and kidney protection, reduce inflammation and oxidative stress, and broaden The effect of applying the foreground

Active Publication Date: 2017-09-19
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Glucose is the only energy supplement in the known GIK formula, but intravenous infusion of glucose often causes large fluctuations in human blood sugar levels and is not effective in patients with diabetes and insulin resistance

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  • A kind of improved polarization liquid and its preparation method and application
  • A kind of improved polarization liquid and its preparation method and application
  • A kind of improved polarization liquid and its preparation method and application

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0026] The improved polarization solution disclosed by the invention is composed of raw materials: 50-200 g / L of fructose, 50-200 g / L of glucose, 30-70 U / L of insulin, and 50-100 mmol / L of potassium chloride. The mass ratio of fructose and glucose in the drug mixture is 1:1, and 3 g of monosaccharides (including fructose and glucose) are added per 1 unit (U) of insulin. The composition of the improved polarized solution contains fructose, glucose and insulin, and the ratio of sugar and insulin in the improved polarized solution is set at 1:3, which not only reduces the incidence of blood sugar rise caused by infusion of polarized solution , while quickly providing energy for the body, it has less impact on blood sugar fluctuations, and can also provide the body with a large dose of insulin, w...

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Abstract

The invention discloses an improved polarizing liquid and its preparation method and application. The composition of the improved polarizing solution is: fructose 50-200g / L, glucose 50-200g / L, insulin 30-70U / L, potassium chloride 50-100mmol / L, and the solvent is water for injection. Preparation method: take fructose, glucose and potassium chloride, add water for injection to dissolve, depyrogenate, sterilize, and dry to make drug mixture component A; then take drug component B composed of insulin alone; Adding it to component A of the drug mixture prepares an improved polarizing solution. The improved polarization solution (FGIK) of the present invention can reduce the oxidative stress of post-traumatic liver and kidney tissues, and has a certain antioxidant effect. FGIK can be used as an adjuvant therapy for the protection of important organ functions after trauma, and has a potentially broad application prospect. Therefore, it can be applied in the preparation of drugs for liver and / or kidney tissue repair after trauma or operation.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a polarizing liquid, in particular to an improved polarizing liquid and its preparation method and application. Background technique [0002] In 1962, Sodi-pallares first proposed that glucose-insulin-potassium (GIK) could be used as an adjuvant therapy for ischemic heart disease. The known composition and dosage of GIK are: 250-300g / L glucose, 50-60U / L insulin, 80mmol / L potassium chloride. Known uses of GIK: ① Stimulation of cardiomyocyte Na + -K + -ATPase, promotes K uptake by cardiomyocytes + , thereby stabilizing the polarization state of the cell membrane and reducing the occurrence of arrhythmia. ②Provide more energy (glucose) to the ischemic myocardium, and insulin inhibits the uptake and utilization of free fatty acids by the ischemic myocardium, and at the same time promotes the uptake and utilization of glucose by the ischemic myocardium, and finally promotes the func...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61P1/16A61P13/12A61P29/00A61P39/06A61K31/7004A61K33/14
Inventor 李嘉董玲张聚磊杨璐张星高峰
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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