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Improved polarizing liquor and preparation method as well as application thereof

A technology of polarizing liquid and potassium chloride, applied in the field of medicine, can solve the problems of poor effect and fluctuation of blood sugar level in patients with diabetes and insulin resistance, achieve good liver and kidney protection, reduce inflammatory response and oxidative stress, broad The effect of the application foreground

Active Publication Date: 2015-06-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Glucose is the only energy supplement in the known GIK formula, but intravenous infusion of glucose often causes large fluctuations in human blood sugar levels and is not effective in patients with diabetes and insulin resistance

Method used

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  • Improved polarizing liquor and preparation method as well as application thereof
  • Improved polarizing liquor and preparation method as well as application thereof
  • Improved polarizing liquor and preparation method as well as application thereof

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0026] The improved polarization solution disclosed by the invention is composed of raw materials: 50-200 g / L of fructose, 50-200 g / L of glucose, 30-70 U / L of insulin, and 50-100 mmol / L of potassium chloride. The mass ratio of fructose and glucose in the drug mixture is 1:1, and 3 g of monosaccharides (including fructose and glucose) are added per 1 unit (U) of insulin. The composition of the improved polarized solution contains fructose, glucose and insulin, and the ratio of sugar and insulin in the improved polarized solution is set at 1:3, which not only reduces the incidence of blood sugar rise caused by infusion of polarized solution , while quickly providing energy for the body, has less impact on blood sugar fluctuations, and can also provide the body with a large dose of insulin, whic...

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Abstract

The invention discloses improved polarizing liquor and a preparation method as well as application thereof. The composition of the improved polarizing liquor comprises the following components: 50-200 g / L of fructose, 50-200 g / L of glucose, 30-70 U / L of insulin and 50-100 mmol / L of potassium chloride, wherein the solvent is water for injection. The preparation method comprises the following steps: taking the fructose, the glucose and the potassium chloride, adding the water for injection for dissolving, removing pyrogen, sterilizing and drying to prepare a medicinal mixture component A; taking the medicinal component B constituted by the insulin independently; adding the medicinal component B into the medicinal mixture component A to prepare the improved polarizing liquor. According to the improved polarizing liquor (FGIK), the oxidative stress of liver and kidney tissues after trauma can be relieved, and the polarizing liquor has a certain anti-oxidation effect. The FGIK can be used for adjuvant therapy for protection of functions of important organs after trauma, and has potential broader application prospect. Thus, the polarizing liquor can be applied to preparing a medicament for liver and / or kidney tissue repair after trauma or operation.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a polarizing liquid, in particular to an improved polarizing liquid and its preparation method and application. Background technique [0002] In 1962, Sodi-pallares first proposed that glucose-insulin-potassium (GIK) could be used as an adjuvant therapy for ischemic heart disease. The known composition and dosage of GIK are: 250-300g / L glucose, 50-60U / L insulin, 80mmol / L potassium chloride. Known uses of GIK: ① Stimulation of cardiomyocyte Na + -K + -ATPase, promotes K uptake by cardiomyocytes + , thereby stabilizing the polarization state of the cell membrane and reducing the occurrence of arrhythmia. ②Provide more energy (glucose) to the ischemic myocardium, and insulin inhibits the uptake and utilization of free fatty acids by the ischemic myocardium, and at the same time promotes the uptake and utilization of glucose by the ischemic myocardium, and finally promotes the func...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61P1/16A61P13/12A61P29/00A61P39/06A61K31/7004A61K33/14
Inventor 李嘉董玲张聚磊杨璐张星高峰
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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