Preparation method of vitamin C

A technology of vitamins and gulonic acid, applied in the direction of organic chemistry, etc., can solve the problems of high cost, harsh reaction conditions, cumbersome process, etc., and achieve the effects of short reaction time, mild reaction conditions and simple process

Active Publication Date: 2015-06-10
安徽泰格生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the above-mentioned preparation methods all have defect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] At room temperature, take 1200g gulonic sodium salt crystals and put them into a 5L closed reactor, add 2000ml 30% hydrochloric acid, stir for 30 minutes, cool the system down to -10℃, and control the pressure difference between the system pressure and the normal pressure to 0.03Mpa , Pour in HCl gas until the system pressure is 0.1MPa higher than normal pressure, close the reactor airtight valve, heat up to 45℃, keep for 5h, open the reactor airtight valve to release the pressure, cool the reaction liquid, precipitate NaCl crystals, filter and remove salt, Then the filtrate was concentrated and cooled to crystallize to obtain Vc.

Embodiment 2

[0026] Vitamin C was prepared by the method of Example 1, with the difference that: the mass concentration of the hydrochloric acid solution was 0% (ie, water), and the cooling was lowered to 0°C.

Embodiment 3

[0028] Vitamin C was prepared by the method of Example 1, with the difference that: the pressure difference between the system pressure and the normal pressure before the introduction of HCl gas was 0.095Mpa, and the pressure difference between the system pressure and the normal pressure after the ventilation was 0.1MPa.

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PUM

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Abstract

The invention relates to a preparation method of vitamin C. The preparation method comprises the following steps: by using gulonic acid inorganic salt or gulonic acid as the raw material, adding a 0-38 wt% hydrochloric acid solution, stirring, cooling, introducing HCl gas, heating, and keeping the temperature until the reaction finishes, thereby obtaining the vitamin C. The preparation method has the advantages of simple technique, short reaction time and more environment-friendly production environment, obviously enhances the vitamin C quality and is suitable for vigorous popularization.

Description

Technical field [0001] The invention relates to a method for preparing vitamin C by using gulonic acid inorganic salt or gulonic acid in one step, and belongs to the technical field of vitamin C synthesis. Background technique [0002] The existing industrialized production of vitamin C generally uses a two-step fermentation method to prepare vitamin C, including fermentation, extraction, and conversion. Among them, the conversion process is that the C-4 position of 2-keto-L-gulonic acid is prone to loss of water and lactonization reaction occurs, while the ketone group at C-2 position is prone to ene purification reaction, lactonization reaction and ene Alcoholization reactions must occur in the presence of acid or base catalysts, so the conversion process is divided into acid conversion and alkali conversion according to different catalysts. [0003] The acid conversion method uses concentrated hydrochloric acid to catalyze 2-keto-L-gulonic acid to prepare vitamin C in one step....

Claims

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Application Information

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IPC IPC(8): C07D307/62
CPCC07D307/62
Inventor 魏升平
Owner 安徽泰格生物技术股份有限公司
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