Composition for improving sleep quality and preparation of composition

A technology for improving sleep quality and composition, applied in the directions of drug combination, food preparation, food science, etc., can solve the problem that the effect of improving sleep quality is not very significant, so as to shorten the induced sleep latency, prolong the induced sleep time, and reduce the use of drugs. amount of effect

Inactive Publication Date: 2015-06-24
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are only more than 400 domestic health foods that have been approved in my country to improve sleep function. The effect of these health foods on improving

Method used

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  • Composition for improving sleep quality and preparation of composition
  • Composition for improving sleep quality and preparation of composition
  • Composition for improving sleep quality and preparation of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Extending sleep time experiment

[0032] Experimental animals: SPF-level Kunming female mice, 6-8 weeks old (weight: 18g-22g), provided by Guangdong Medical Laboratory Animal Center, production license number: SCXK (Guangdong) 2013-0002, quality certificate number : No.44007200011089.

[0033] Test method: After the experimental animals were quarantined under laboratory conditions for three days, each of the following experiments randomly divided 84 mice into 7 experimental groups with 12 animals in each group. The test substance was given by gavage daily, and the amount of sample was given. Adjusted according to weekly weight gain and loss, the experiment time is 4 weeks. The application plan is shown in Table 1:

[0034] Table 1 Application scheme

[0035]

[0036] During the experiment, the weight of the sample was weighed, and a 50.0 mL sample solution was prepared with purified water for the animal to be used by gavage. The test substance was administered oral...

Embodiment 2

[0045] Example 2 Sleep latency experiment of barbital sodium

[0046] Experimental animals: SPF-level Kunming female mice, 6-8 weeks old (weight: 18g-22g), provided by Guangdong Medical Laboratory Animal Center, production license number: SCXK (Guangdong) 2013-0002, quality certificate number : No.44007200011089.

[0047] Test method: After the experimental animals were quarantined under laboratory conditions for three days, each of the following experiments randomly divided 84 mice into 7 experimental groups with 12 animals in each group. The test substance was given by gavage daily, and the amount of sample was given. Adjusted according to weekly weight gain and loss, the experiment time is 4 weeks. The application scheme is the same as in Example 1.

[0048] During the experiment, the weight of the sample was weighed, and a 50.0 mL sample solution was prepared with purified water for the animal to be used by gavage. The test substance was administered orally to animals in an am...

Embodiment 3

[0056] Example 3 Preparation of health food tablets

[0057] The formula of the health food tablet is shown in Table 4.

[0058] Table 4 Formula of health food tablets

[0059]

[0060] The production process is as follows:

[0061] Add the feed amount of casein hydrolysate, isomalt, microcrystalline cellulose, gamma-aminobutyric acid, and magnesium stearate into the mixer and mix evenly until the material has a uniform color and texture. The mixing time is 10-30 minutes. Press the tablet with a tablet press and check the difference in tablet weight every 15 minutes.

[0062] According to the process requirements, the film coating agent and purified water are weighed to prepare a film coating slurry. The slurry can be sprayed after the stirring time is 45 minutes, and the stirring is not stopped during the coating process. Open the coating pan door, weigh the plain tablets and send them into the coating pan. Adjust the distance between the spray gun and the film bed. The spray gun i...

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Abstract

The invention relates to the field of health food, in particular to a composition for improving sleep quality and a preparation of the composition. The composition comprises gamma-aminobutric acid and casein hydrolysate. The gamma-aminobutric acid and the casein hydrolysate are composed to use, pentobarbital sodium induced sleeping time can be obviously prolonged, pentobarbital sodium induced sleeping time incubation period is shortened, a function of sleeping improvement is obviously achieved, and good or even better effect can be achieved in case of reducing doses.

Description

Technical field [0001] The invention relates to the field of health foods, in particular to a composition and preparations for improving sleep quality. Background technique [0002] Sleep is the basic way of life of human beings and it is indispensable. Sleep has a protective and repairing effect on brain cell function. Long-term lack of sleep will degrade brain function. Healthy sleep helps anti-aging. Adequate sleep can strengthen the body's resistance and immunity. Frequent lack of sleep can make people feel anxious and anxious, and weaken their immunity, which can lead to various diseases, such as neurasthenia, colds, and gastrointestinal diseases. Therefore, adequate sleep is of great significance to human development and physical health. The survey results show that about 45.4% of people in my country suffer from insomnia to varying degrees. The incidence of poor sleep quality tends to increase with age. Undergraduates have sleep disorders ranging from 15% to 38%, and 39...

Claims

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Application Information

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IPC IPC(8): A23L1/305A61K38/01A61P25/20A23L33/175A23L33/18
CPCA61K38/01A23V2002/00A23V2200/31
Inventor 黄远英殷光玲
Owner BY HEALTH CO LTD
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