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Application of hydroxysafflor yellow A in preparation of health drug or functional food for treating hypoxic pulmonary hypertension

A technology of pulmonary arterial hypertension and hydroxy safflower, applied in the field of medicine, can solve the problems of reducing myocardial infarction area, reducing heart rate, reducing blood pressure, etc.

Active Publication Date: 2015-06-24
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxysafflower yellow A, the main component of safflower, has various pharmacological activities. Hydroxysafflower yellow A can antagonize platelet activating factor receptor binding; reduce myocardial infarct size; lower blood pressure, antithrombotic and inhibit platelet aggregation etc.; Hydroxy safflower yellow A can significantly reduce blood pressure and reduce heart rate, and hydroxy safflower yellow A can also inhibit apoptosis and protect cell cycle from damage to human umbilical vein endothelial cells caused by hypoxia; in addition, hydroxy safflower yellow A also has anti-oxidation and anti-tumor effects, but there is no research report on its use in pulmonary arterial hypertension (Pulmonary Arterial Hypertension, PAH).

Method used

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  • Application of hydroxysafflor yellow A in preparation of health drug or functional food for treating hypoxic pulmonary hypertension
  • Application of hydroxysafflor yellow A in preparation of health drug or functional food for treating hypoxic pulmonary hypertension
  • Application of hydroxysafflor yellow A in preparation of health drug or functional food for treating hypoxic pulmonary hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the preparation of hydroxy safflower yellow A

[0038] 1.1 Grind dried safflower with a Chinese herbal medicine grinder, weigh 700g of dried safflower powder, add 7000ml of water to soak for 24h, then heat in a water bath at 50°C for 1h, ultrasonic at 50°C for 10 minutes, filter with 4 layers of gauze, and filter the total filtrate with suction. Obtain filtrate 1 and filter residue for use. The filter residue was heated again in a water bath at 50°C for 1 hour, ultrasonicated at 50°C for 10 minutes, filtered with 4 layers of gauze and suction filtered to obtain filtrate 2. Combine filtrate 1 and filtrate 2, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70% v / v, refrigerate, let stand for 48 hours, filter, recover ethanol from the filtrate, and concentrate To a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80% v / v, refrigerate, let stand for 48 hours, filter...

Embodiment 2

[0042] Example 2: Effects of Hydroxysafflower Yellow A on Microstructure of Pulmonary Arterioles in Hypoxic Rats and Inhibition of Pulmonary Arterial Vascular Structural Reconstruction and Right Ventricular Hypertrophy

[0043] Thirty male Wistar rats with body weight (160±109g) (provided by the Experimental Animal Center of Daqing Campus, Harbin Medical University) were randomly divided into 4 groups: control group, hypoxia group, hydroxysafflor yellow A+ hypoxia group . The hypoxia group and the hypoxia administration group rats were placed in a plexiglass container box with normal pressure and low oxygen, nitrogen gas was introduced, mixed with air, and the oxygen concentration was controlled to be (10 ± 0.5)% with an automatic oxygen measuring instrument. The temperature sensor control circuit can keep the temperature in the cabin constant all the time, absorb the moisture in the box with anhydrous calcium chloride to maintain its humidity, and absorb the carbon dioxide in...

Embodiment 4

[0064] Example 4: Safflower injection technological process investigation and stability research

[0065] 1. Preparation process of 2010 Pharmacopoeia Safflower Injection

[0066] Take 500g of safflower, add water and decoct three times, the first time is 1 hour, the second time is 50 minutes, the third time is 30 minutes, the decoction is combined, filtered, the filtrate is concentrated to a relative density of 1.161-26, and ethanol is added to make the ethanol content reach 70%, refrigerate, stand still for 48 hours, filter, filtrate recover ethanol, and concentrate to a relative density of 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand still for 48 hours, filter, filtrate Recover ethanol and concentrate to a relative density of 1.16-1.20, add 10 times the amount of water, refrigerate, let stand for 16-24 hours, filter, concentrate the filtrate to a relative density of 1.02-1.04, adjust the pH with 50% sodium hydroxide solution Value 7.5-8....

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Abstract

The invention discloses application of hydroxysafflor yellow A in preparation of health care drugs or functional food for treating hypoxic pulmonary hypertension. The hydroxysafflor yellow A has the function of inhibiting pulmonary vascular structure remodeling and right ventricular hypertrophy caused by anoxia. The invention further relates to a method for extracting hydroxysafflor yellow A from traditional Chinese medicine safflower. According to the invention, a new technological means for researching and developing the safflower medicinal resource is provided, a research is made on the function of the effective component hydroxysafflor yellow A of safflower for inhibiting pulmonary hypertension, and the result indicates that the hydroxysafflor yellow A can effectively improve the pulmonary artery remodeling of hypoxic pulmonary hypertension rats and reduce pulmonary arterial pressure, so the hydroxysafflor yellow A is expected to be used in the prevention and treatment of pulmonary hypertension.

Description

technical field [0001] The present invention relates to a new drug application of a chalcone derivative hydroxysafflower yellow A isolated from the traditional Chinese medicine safflower, in particular to the preparation of hydroxysafflower yellow A health medicine or functional food for treating hypoxic pulmonary hypertension The invention belongs to the technical field of medicine. Background technique [0002] Pulmonary arterial hypertension (Pulmonary Artery Hypertension, PAH) is an extremely malignant progressive disease. Due to the continuous increase of pulmonary artery pressure caused by pulmonary artery obstruction, it will eventually lead to right ventricular failure and premature death. It is second only to coronary heart disease and hypertension. The third common cardiovascular disease. Most patients will die of heart failure within 2 to 3 years. The prognosis is only better than liver cancer, and worse than other tumors. The survival rate of patients is very lo...

Claims

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Application Information

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IPC IPC(8): A61K31/351A61P9/12A61P11/00A23L1/30A23L33/105
Inventor 杨宝峰白玉华于学丽李磊吴立军
Owner HARBIN MEDICAL UNIVERSITY
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