Method for producing microcarriers

A technology of microcarriers and ontology, applied in the field of microcarriers, can solve problems such as separation and error, and achieve the effect of improving mechanical properties and reliable analysis

Inactive Publication Date: 2015-06-24
麦卡提斯有限责任公司
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0017] Furthermore, during the process described in WO 2011 / 044708, some microcarriers would tumble before coating thus resulting in coating on the wrong surface
[0018] Additionally, it was not possible to separate partially coated microcarriers 1b or uncoated microcarriers from well-coated microcarriers 1a prior to fluorescence analysis
Indeed, the presence of an optical layer on a microcarrier can only be identified by the emitted fluorescent signal during fluorescence analysis.

Method used

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  • Method for producing microcarriers
  • Method for producing microcarriers
  • Method for producing microcarriers

Examples

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Embodiment Construction

[0057] The following will refer to Figures 6 to 17 Methods of making microcarriers according to the invention are described. The method comprises the following sequential steps:

[0058] first step, such as Figure 4 As shown, there is provided a wafer 6 having a sandwich structure, the wafer 6 comprising a bottom layer 7, a top layer 8 and an insulating layer 9 between said bottom layer and top layer 7,8.

[0059] For example, the wafer 6 is an SOI (silicon on insulator) wafer having a bottom layer 7 with a diameter of 100 mm and a thickness of 380 μm, an insulating layer 9 with a thickness of 1 μm and a top layer 8 with a thickness of 10 μm. The top layer 8 and the bottom layer 7 are made of monocrystalline silicon, and the insulating layer 9 is made of silicon dioxide.

[0060] The second step, such as Figure 5 As shown, a photoresist layer 10 is applied on top layer 8 . In order to outline the surface of the microcarriers, the photoresist layer 10 is irradiated with...

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Abstract

The present invention relates to a method for producing microcarriers comprising the following steps: (a) providing a wafer (6) having a sandwich structure comprising a bottom layer (7), a top layer (8) and a insulating layer (9) located between said bottom and top layers (7, 8), (b) etching away the top layer (8) to delineate lateral walls (12) of bodies (11) of the microcarriers, (c) depositing a first active layer (13) at least on a top surface (14) of the bodies (11), (d) applying a continuous polymer layer (16) over the first active layer (13), (e) etching away the bottom layer (7) and the insulating layer (9), (f) removing the polymer layer (16) to release the microcarriers.

Description

technical field [0001] The invention relates to a method for manufacturing microcarriers and a microcarrier. In particular, the invention relates to microcarriers suitable for carrying out biological and / or chemical analyzes in scientific and clinical laboratories. Background technique [0002] Within the scope of the present invention, microcarriers or microparticles, respectively, refer to any type of carrier or particle of minute size, with a typical maximum dimension of 100 nm to 300 μm, preferably 1 μm to 200 μm. [0003] According to the present invention, the term microcarrier refers to a functionalized, or adapted to be functionalized, microparticle comprising, or adapted to comprise, one or more ligands attached to the surface of the microcarrier or impregnated into its bulk or functional units. A broad spectrum of chemical and biological molecules can be attached to microcarriers as ligands. A microcarrier can have multiple functional units and / or ligands. Here...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B81C1/00G01N15/14G01N33/543B01L3/00B81C99/00
CPCB01L3/502707B01L3/502761B01L3/508B01L3/54B01L3/545B81C99/008G01N33/54313B01L2200/0647B01L2200/10B01L2200/12B01L2300/0803B01L2300/0819B01L2300/0851B01L2300/0893B81B2201/058B81B2201/06B01J2219/005B01J2219/00502B01J2219/00536B01J2219/00556B01J2219/00637B81C1/00H01G13/06
Inventor 拉斐尔·托尔奈尼古拉斯·德米埃尔斯蒂芬·甘伯菲利普·赫诺
Owner 麦卡提斯有限责任公司
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