Collagen gel containing nanogold, and prepetition method and application thereof
A collagen gel and nano-gold technology, which is used in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of allergic reactions, unstable mask properties, and single effect, avoiding protein denaturation and anti-oxidation. controllable effect
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Embodiment 1
[0037] Prepare an aqueous collagen solution containing 1 mg / ml from bovine Achilles tendon, add 10 μl of 0.1 M chloroauric acid solution to 1 ml of the collagen solution, and oscillate to mix evenly. After standing at 10° C. for 72 hours, a collagen gel containing gold nanoparticles was obtained.
[0038] The physical picture of the obtained collagen gel is attached figure 1 , figure 1 It is a collagen hydrogel containing gold nanoparticles prepared in a test tube. The gel does not flow after inversion, and the color of the gel comes from the gold nanoparticles synthesized in situ.
Embodiment 2
[0040] Aqueous fish skin collagen solution containing 10mg / ml extracted from fish skin is prepared to prepare a 0.01M gold chloride aqueous solution. Slowly add 100 μl of gold chloride aqueous solution into 1 ml of fish skin collagen solution along the side wall, shake to mix evenly. The mixed solution was placed at 65° C. for 1 h to obtain a collagen gel containing gold nanoparticles.
[0041] The ultraviolet-visible spectrogram of the obtained collagen gel is as attached figure 2 , the absorption peak at 550nm is the characteristic absorption peak of nano-gold particles, indicating that the collagen gel can successfully synthesize nano-gold particles in situ, and the collagen gel containing nano-gold particles can be obtained by using this method.
Embodiment 3
[0043]Take 10 mg of bovine skin collagen and dissolve it in 1 ml of aqueous solution, and add 10 μl of 0.5 mg / ml hyaluronic acid aqueous solution dropwise to the uniform collagen solution. Prepare a 0.1M aqueous gold chloride solution, add 20 μl of the aqueous gold chloride solution to the above mixture, shake to mix evenly. The final mixture was placed at 25° C. for 72 hours to obtain an antioxidant collagen gel added with hyaluronic acid aqueous solution.
[0044] The scanning electron microscope picture of the obtained collagen gel is attached image 3 , the scanned pictures clearly show that the obtained collagen gel is fibrous, and the white matter evenly distributed on the collagen fibers is gold nanoparticles.
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