Collagen gel containing nanogold, and prepetition method and application thereof

A collagen gel and nano-gold technology, which is used in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of allergic reactions, unstable mask properties, and single effect, avoiding protein denaturation and anti-oxidation. controllable effect

Active Publication Date: 2015-07-01
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such technologies require the addition of cross-linking agents, which may cause adverse consequences such as unstable properties of the mask, allergic react

Method used

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  • Collagen gel containing nanogold, and prepetition method and application thereof
  • Collagen gel containing nanogold, and prepetition method and application thereof
  • Collagen gel containing nanogold, and prepetition method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prepare an aqueous collagen solution containing 1 mg / ml from bovine Achilles tendon, add 10 μl of 0.1 M chloroauric acid solution to 1 ml of the collagen solution, and oscillate to mix evenly. After standing at 10° C. for 72 hours, a collagen gel containing gold nanoparticles was obtained.

[0038] The physical picture of the obtained collagen gel is attached figure 1 , figure 1 It is a collagen hydrogel containing gold nanoparticles prepared in a test tube. The gel does not flow after inversion, and the color of the gel comes from the gold nanoparticles synthesized in situ.

Embodiment 2

[0040] Aqueous fish skin collagen solution containing 10mg / ml extracted from fish skin is prepared to prepare a 0.01M gold chloride aqueous solution. Slowly add 100 μl of gold chloride aqueous solution into 1 ml of fish skin collagen solution along the side wall, shake to mix evenly. The mixed solution was placed at 65° C. for 1 h to obtain a collagen gel containing gold nanoparticles.

[0041] The ultraviolet-visible spectrogram of the obtained collagen gel is as attached figure 2 , the absorption peak at 550nm is the characteristic absorption peak of nano-gold particles, indicating that the collagen gel can successfully synthesize nano-gold particles in situ, and the collagen gel containing nano-gold particles can be obtained by using this method.

Embodiment 3

[0043]Take 10 mg of bovine skin collagen and dissolve it in 1 ml of aqueous solution, and add 10 μl of 0.5 mg / ml hyaluronic acid aqueous solution dropwise to the uniform collagen solution. Prepare a 0.1M aqueous gold chloride solution, add 20 μl of the aqueous gold chloride solution to the above mixture, shake to mix evenly. The final mixture was placed at 25° C. for 72 hours to obtain an antioxidant collagen gel added with hyaluronic acid aqueous solution.

[0044] The scanning electron microscope picture of the obtained collagen gel is attached image 3 , the scanned pictures clearly show that the obtained collagen gel is fibrous, and the white matter evenly distributed on the collagen fibers is gold nanoparticles.

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Abstract

The invention discloses a collagen gel containing nanogold, and a preparation method and an application thereof. The gel is prepared by the method of reducing a gold precursor by collagen. Firstly, reducing groups in collage react with the gold precursor to generate nanogold, then the generated nanogold further crosses link a three-screw structure of collagen in situ, to form compact gel. The property stability of the collagen is even, the particle size of contained nanogold is controllable, the preparation process is simple and convenient, chemical cross linking agent is not required, and so the collagen gel has a wide application prospect in the fields of daily cosmetic antioxidant masks and the like.

Description

technical field [0001] The invention relates to the technical field of daily necessities, in particular to a collagen gel containing nano-gold and its preparation method and application. Background technique [0002] With the improvement of people's living standards, beauty and health are getting more and more attention. The rapid changes in the cosmetics industry have further strengthened people's attention to health and beauty. There are many types of mask products on the market, but most of the mask materials have complex preparation processes and cumbersome procedures, and more or less substances harmful to the skin such as reducing substances, cross-linking agents, and ethanol solvents are added during the preparation process. . Therefore, it is necessary to simplify the production process and prepare a pure natural, chemical-free facial mask. [0003] Collagen is the main component of animal connective tissue, and it is also the most abundant and widely distributed ...

Claims

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Application Information

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IPC IPC(8): A61K8/65A61K8/19A61K8/02A61Q19/02A61Q19/08A61Q19/00
Inventor 闫学海邢蕊蕊邹千里陈成军刘凯马光辉
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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