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Medicinal use of notoginseng saponin r1

A technology of Panax notoginseng saponins and drugs, which is applied in the field of medical use of Panax notoginseng saponins R1, can solve the problems of reduced ability to eliminate bacteria, influence of wound healing, poor blood sugar control and the like

Active Publication Date: 2019-12-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the blood sugar control of diabetic patients is not good, and the body's ability to eliminate bacteria will be reduced
High blood sugar can reduce the ability of cells to transport oxygen to tissues, resulting in poor blood circulation and affecting wound healing

Method used

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  • Medicinal use of notoginseng saponin r1
  • Medicinal use of notoginseng saponin r1
  • Medicinal use of notoginseng saponin r1

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0036] 1. Experimental materials

[0037] 1.1 Medicinal materials

[0038] Notoginsenoside R1 (CAS: 80418-24-2, molecular weight 933.13, HPLC purity ≥ 98%, Shanghai Yilin Biotechnology Co., Ltd.)

[0039] 1.2 Experimental animals

[0040] db / db female mice (12 weeks) weighing 50±5g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SCXK (Beijing) 2011-0012. Placed in a conventional feeding environment, housed in separate cages, free to eat and drink.

[0041] 2. Experimental method

[0042] 2.1 Establishment of diabetes injury model

[0043] Using the modeling method in the literature (Nature Protocols, 2013, 8:302-309), after isoflurane anesthesia, the back skin was shaved, and the skin was disinfected routinely. A hole punch with a diameter of 6 mm was used to cut a circle on both sides of the back spine. Shaped incision, deep to the fascia. In order to prevent the wound from shrinking auto...

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Abstract

The invention relates to the field of medicine and pharmacology, in particular to medical application of notoginsenoside R1. Animal experiments show that notoginsenoside R1 can effectively promote healing of diabetic wounds and has significance for treatment of diabetic gangrene.

Description

technical field [0001] The invention relates to the field of medicine and health products, in particular to the medical use of a notoginseng saponin R1. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health, and has become the fourth leading cause of death after cardiovascular, tumor and AIDS. Statistics show that there are currently 285 million diabetic patients in the world, and it is predicted that by 2030, the number of diabetic patients in the world will reach 439 million, and the complications caused by diabetes have become the main cause of disability and death of patients. Among the many complications of diabetes, the impaired wound healing ability of diabetic patients is a typical complication of diabetes. If chronic injuries and ulcers occur in the feet, it may cause diabetic foot, and even lead to amputation in severe cases. Diabetes is the disease with the highest hospitalization rate, and it is reported that there i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P17/02A23L33/10A61K8/63A61Q11/00
Inventor 王峥涛张二云高波黄玲芳杨莉吴晓俊
Owner SHANGHAI UNIV OF T C M
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