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Melanoma cold and hot therapy device

A melanoma and treatment device technology, applied in the field of biomedical engineering, can solve the problems of limited therapeutic effect and inability to effectively alleviate the immune suppression microenvironment of the body, and achieve the effect of inhibiting distant metastasis, improving survival rate, and improving immune response

Active Publication Date: 2015-07-22
MAGI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current conventional cancer treatment methods cannot effectively relieve the body's immunosuppressive microenvironment, thereby effectively stimulating the body to generate a systemic anti-tumor immune response and inhibiting the development of cancer metastasis. The therapeutic effect is very limited.

Method used

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  • Melanoma cold and hot therapy device
  • Melanoma cold and hot therapy device
  • Melanoma cold and hot therapy device

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Please refer to figure 1 , the device mainly utilizes the treatment control system to control the alternating use of the cold source and the heat source, so as to achieve tumor ablation and distant metastasis inhibition. The device includes a treatment control system A and a tumor treatment unit B, wherein the treatment control system A is composed of a small industrial computer 1 and a display monitoring module 2, wherein the small industrial computer is integrated with a high-speed data acquisition board for Real-time collection of tissue temperature data and relevant treatment parameter data during the treatment process, and through industrial computer program control, a numerical control signal is generated to control the work of the tumor treatment device; the tumor treatment unit B includes a control circuit 3, a cold source 4, and a heat source 5 , temperature sensor 6, conformal probe 7.

[0034] The treatment control system A in the cold and heat treatment dev...

Embodiment 2

[0038] figure 2 It is a structural schematic diagram of a preferred embodiment of the conformal probe 7 of the present invention. In this preferred embodiment, liquid refrigerant is used for cold therapy, and radio frequency or microwave is used for thermal therapy; the conformal probe has a refrigerant flow channel and a refrigerant The inlet 71 and the refrigerant outlet 72 also have a heat source connection port 73. The inner wall of the conformal probe is made of metal, which can conduct the heat source to the conformal treatment surface 74 (the shape of the conformal treatment surface is not unique, any Any shape suitable for closely fitting the tumor surface can be adopted), meanwhile, the outer wall of the probe is protected by a heat insulating layer 75 made of an insulating material. During cryotherapy, the refrigerant enters the probe through the refrigerant inlet 71, and takes away the heat after heat exchange on the conformal treatment surface 74, and the vaporize...

Embodiment 3

[0040] The cold and heat treatment device of the present invention can efficiently treat melanoma. In this embodiment, the present invention is used to treat melanoma in mice to obtain a good therapeutic effect. The specific experimental process is as follows:

[0041] 1. Materials and Methods

[0042] 1.1 Animals, cell lines and main reagents

[0043] Six to eight-week-old SPF grade C57BL / 6 female mice (Shanghai Slack Animal Center) were reared in cages with independent ventilation boxes, and the light was changed artificially for 12 hours day and night. Mice freely ingested 60Co radiation sterilized feed and high temperature sterilized water. Mouse B16F10 melanoma cells (ATCC) were cultured in a medium supplemented with 10% newborn fetal bovine serum (Hangzhou Sijiqing Co., Ltd.) and double antibodies (100U / mL penicillin, 100g / mL streptomycin) (Shanghai Sangon Biological Engineering Co., Ltd. Technology Services Co., Ltd.) in RPMI1640 medium (Hyclone, USA).

[0044] 1.2 ...

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Abstract

The invention discloses a melanoma cold and hot therapy device. The melanoma cold and hot therapy device comprises a therapy control system and a tumor therapy unit. The therapy control system comprises a small industrial personal computer and a display monitoring module and is used for controlling the tumor therapy unit to achieve cooperative work, so that automatic program control therapy of melanoma is achieved, and the therapy process can be displayed and monitored in real time. The tumor therapy unit comprises a cold source, a hot source, a conformal probe, a device control circuit and the like and is mainly used for achieving melanoma tissue therapy. Furthermore, the temperature of melanoma tissue can be fed back through a temperature sensor, and thus the therapy temperature can be better adjusted. The melanoma cold and hot therapy device is easy to operate, capable of completely melting tumor-in-situ tissue and improving the immune response of a living body, and obvious in application effect.

Description

technical field [0001] The invention relates to a cold and heat alternating treatment device for melanoma, which belongs to the field of biomedical engineering. Background technique [0002] Melanoma is a highly malignant tumor formed by the malignant transformation of melanocytes. It is highly invasive and prone to distant metastasis. Common metastatic sites include lung, bone and liver. The average survival period of patients with advanced melanoma is only 6-9 months, which brings great harm to human life. [0003] For a long time, the treatment of melanoma has been in the stage of tackling key problems in the medical field. The conventional method for the clinical treatment of melanoma is local excision. Other treatments include immunotherapy (vaccine), gene therapy, chemotherapy, and radiotherapy. Local excision, as a routine treatment, has extremely poor prognosis. Accurate and easy to increase the chance of residual tumor; melanoma is not sensitive to chemotherapy an...

Claims

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Application Information

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IPC IPC(8): A61B18/02A61B18/12A61B18/18
CPCA61B18/02A61B18/04
Inventor 徐学敏张爱丽刘苹白景峰孙建奇邹金成
Owner MAGI CO LTD