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Mongolian medicine piper longum extract used for reducing blood fat

An extract and blood lipid-lowering technology, which is applied in the field of traditional Chinese medicine extracts, can solve problems such as toxicity, and achieve the effect of improving the extraction rate and simple operation of the method

Inactive Publication Date: 2015-08-05
薄彧坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research carried out for this purpose proved that piperine in Piperia can inhibit both endogenous and exogenous blood lipid elevation, and at the same time it was learned that piperine may also be toxic.

Method used

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  • Mongolian medicine piper longum extract used for reducing blood fat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Purchase 200.00 g of commercially available Mongolian medicinal materials-dried Piperia fruit, carry out ultrafine grinding, pulverize to a particle size of 100-120 μm, put it in a container, then add 2.5 L of ethanol solution with an ethanol mass fraction of 80 wt%, and carry out at 45°C Ultrasonic extraction, the ultrasonic power is 600W, extract for 5 hours, filter to obtain the extract; the extract is adsorbed by silica gel chromatography column, eluted with water for 3 column volumes, the eluent is discarded, and then methanol-chloroform (methanol and The volume ratio of chloroform is 1: 3.5) as the eluent, eluting, and collecting the eluent; the above-mentioned eluent is concentrated under reduced pressure to obtain a dry extract; the acetone mass fraction of the above-mentioned dry extract is 80wt% Dissolve the acetone solution, put on the AB-8 macroporous adsorption resin column, then use the acetone mass fraction of 3 times column volume as the acetone solution ...

Embodiment 2

[0034] Purchase 200.00 g of commercially available Mongolian medicinal materials-dried Piperia fruit, carry out ultrafine grinding, pulverize to a particle size of 100-120 μm, put it in a container, then add 2.5 L of ethanol solution with a mass fraction of ethanol of 70 wt%, and carry out at 40°C Ultrasonic extraction, the ultrasonic power is 700W, extract for 4 hours, filter to obtain the extract; the extract is adsorbed by silica gel chromatography column, eluted with water for 3 column volumes, the eluent is discarded, and then methanol-chloroform (methanol and The volume ratio of chloroform is 1: 3.5) as eluent, carries out elution, collects this eluent; Above-mentioned eluent is concentrated under reduced pressure, obtains dry extract; The acetone mass fraction of above-mentioned dry extract is 75wt% Dissolve in acetone solution, put on AB-8 macroporous adsorption resin column, then use 3 times column volume of acetone mass fraction as 20wt% acetone solution for elution, ...

Embodiment 3

[0036] Purchase 200.00 g of commercially available Mongolian medicinal materials-dried Piperia piperi fruit, carry out ultrafine grinding, pulverize to a particle size of 100-120 μm, put it in a container, then add 2.5 L of ethanol solution with an ethanol mass fraction of 85 wt%, and carry out at 43°C Ultrasonic extraction, the ultrasonic power is 600W, extract for 6 hours, filter to obtain the extract; the extract is adsorbed by silica gel chromatography column, eluted with water for 3 column volumes, the eluent is discarded, and then methanol-chloroform (methanol and The volume ratio of chloroform is 1: 3.5) as eluent, carries out elution, collects this eluent; Above-mentioned eluent is concentrated under reduced pressure, obtains dry extract; The acetone mass fraction of above-mentioned dry extract is 80wt% Dissolve in acetone solution, put on AB-8 macroporous adsorption resin column, then use 3 times column volume of acetone mass fraction as 20wt% acetone solution for elut...

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Abstract

The invention relates to a Mongolian medicine piper longum extract used for reducing blood fat. The piper longum extract is prepared through following steps: (1) buying market mongolian medicine, dry piper longum fruits, and ultrafine-pulverizing the dry piper longum fruits, adding an ethanol solution being 65-100 wt% in mass percentage, performing ultrasonic extraction at 40-45 DEG C for 4-6 h, and performing filtration to obtain an extract liquid; (2) performing silica gel chromatographic column adsorption to the extract liquid, performing elution with water by three times of the volume of the column, performing elution with methanol-chloroform as an elution liquid and collecting the eluant; (3) performing pressure-reduced concentration to the eluant to obtain a dry extract; (4) dissolving the dry extract with an acetone solution being 75-80 wt% in mass percentage, passing the solution through a macroporous adsorption resin column, performing elution with an acetone solution being 10-20 wt% in mass percentage by three times of the volume of the column and rejecting an eluant, and performing elution with an acetone solution being 75-80 wt% in mass percentage and collecting an eluant; and (5) performing pressure-reduced concentration to the eluant and drying a product to obtain the mongolian medicine piper longum extract.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to the Mongolian medicinal material Piperumba extract used for lowering blood fat. Background technique [0002] Mongolian medicine has a long history. It is a summary of the Mongolian people's long-term experience in fighting diseases and absorbing the experience of Tibetan medicine and Han medicine. It is an important part of Chinese national medicine and a medicine with national characteristics. It has been proved to be an indispensable subject in clinical medicine for thousands of years. The Mongolian medicinal material Piperia is the near-ripe or mature fruit ear of the Piperaceae plant, which belongs to the spleen meridian, stomach meridian, large intestine meridian, lung meridian, bladder meridian, liver meridian, and kidney meridian. Indications for cold pain in the epigastric abdomen, vomiting, diarrhea, migraine, nasal sinusitis, external treatment of toothache, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61P3/06
Inventor 薄彧坤杨丹李焕婷
Owner 薄彧坤
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