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Product made of native silk fibres

A technology for natural silk and products, applied in the field of silk processing, can solve problems such as undiscovered activation, and achieve the effect that the preparation method is robust and suitable for industrial-scale production

Active Publication Date: 2015-08-05
MORPHOMED GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the activation of inflammatory cells including macrophages around native silk fibers has been confirmed, while in the control group without sericin or silk fibroin fibers coated with gelatin, no activation was found.

Method used

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  • Product made of native silk fibres
  • Product made of native silk fibres
  • Product made of native silk fibres

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Experimental program
Comparison scheme
Effect test

Embodiment

[0055] Materials and methods

[0056] Material

[0057] All reagents were obtained from Sigma (Vienna, Austria) and were of analytical grade unless otherwise specified.

[0058] Silk-Matrix Design

[0059] White silkworm silk fiber (20 / 22den, 250T / m) was purchased from Testex AG (Zurich, Switzerland). Braided scaffold (braided scaffold) and Edelrid (Edelrid GmbH, Isny ​​im Germany) co-manufacturing. The braided skeleton is in the form of a cable and can be further divided into a sheath and a core, both of which have a hierarchical structure including threads, bundles, ply yarns and individual silk fibers (see figure 1 ). The basic unit of the braided structure represents a plied yarn formed from 6 individual silk fibers. The construction basis of the sheath and thread is 6 and 24 plied yarns respectively. The whole skeleton is composed as follows: the core component (4 wires) is surrounded by a tubular sheath with a total diameter of 5.8 mm. The tubular structure of ...

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Abstract

Disclosed is a method for the production of two- or three-dimensional silk products, wherein native silk fibres are formed into a two- or three-dimensional silk product and the silk product formed is subjected to a degumming step wherein a borate buffer is used as degumming agent and wherein the silk product formed is preferably contacted with an aqueous ethanol buffer prior to the degumming step.

Description

technical field [0001] The invention relates to the field of processing silk (silk), in particular to provide medical silk materials. Background technique [0002] Silk has been used in biomedical sutures for decades, and a potential host immune response has been observed. This may be the main reason why silk has not been considered in past biomedical applications. The main cause of immune response is related to sericin (review: Altman et al., Biomaterials 24 (2003), 401-416). Therefore, the complete removal of sericin from raw silk is a key step in preparing silk fabrics for tissue engineering and regenerative medicine applications while avoiding biocompatibility issues. [0003] Most often, silk is obtained from the cocoons of the larvae of the silkworm (Bombyx mori). A single silkworm cocoon fiber consists of a colloidal protein called sericin surrounding a core of two fibroin chains, wherein the fibroin fibers are secured to each other by the sericin. Silk fibroin an...

Claims

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Application Information

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IPC IPC(8): D01C3/02A61L27/22
CPCA61L27/3687A61L27/3604D01C3/02A61L27/38A61L27/22A61L27/50A61L31/005A61L31/14A61B17/04A61L27/227A61L27/58A61L2430/10D04B1/14D10B2401/061D10B2401/063D10B2401/12D10B2403/033D10B2509/00
Inventor 安德烈亚斯·托伊舍尔马迪金·范格林斯芬海因茨·雷德尔
Owner MORPHOMED GMBH
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