A kind of sodium tetradecyl sulfate injection and preparation method thereof

A technology of sodium tetradecyl sulfate and injection, which is used in pharmaceutical formulations, medical preparations with inactive ingredients, drug delivery and other directions, can solve the problems of insufficient active ingredient content and poor stability, and achieves high active ingredient content, high good stability

Active Publication Date: 2017-12-05
SPH NO 1 BIOCHEM & PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a Sodium Tetradecyl Sulfate Injection in order to overcome the defects of poor stability and insufficient active ingredient content of the Sodium Tetradecyl Sulfate Injection used in the prior art for treating varicose veins of the lower extremities. and its preparation method

Method used

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  • A kind of sodium tetradecyl sulfate injection and preparation method thereof
  • A kind of sodium tetradecyl sulfate injection and preparation method thereof
  • A kind of sodium tetradecyl sulfate injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0035] Measure 700ml of water for injection, add 5g of anhydrous disodium hydrogen phosphate, stir to dissolve, measure 30ml of benzyl alcohol into the solution and stir to dissolve, measure the pH of the mixed system = 8.42, then weigh 12g of sodium tetradecyl sulfate and add it to the above Stir in the medicinal solution to disperse, and adjust the pH of the medicinal solution to 7.57 with 5.2 ml of sodium dihydrogen phosphate solution (0.5 mol / l). With water for injection, the above-mentioned medicinal solution is settled to 1000ml, and the pH value of retesting is 7.64. Filter and fill.

Embodiment 2

[0037] Measure 700ml of water for injection, add 9g of anhydrous disodium hydrogen phosphate, stir to dissolve, measure 50ml of benzyl alcohol into the solution and stir to dissolve, measure the pH of the mixed system = 8.77, then weigh 30g of sodium tetradecyl sulfate and add it to the above Stir in the medicinal solution to disperse, adjust the pH of the medicinal solution to 7.54 with 5.3ml of sodium hydroxide solution (1.0mol / l), dilute the above-mentioned medicinal solution to 1000ml with water for injection, and retest the pH value to 7.58. Filter and fill.

Embodiment 3

[0039] Measure 700ml of water for injection, add 5g of anhydrous disodium hydrogen phosphate, stir to dissolve, measure 30ml of propylene glycol, add to the solution and stir to dissolve, measure the pH of the mixed system = 8.51, then weigh 12g of sodium tetradecyl sulfate and add it to the above drug Stir in the liquid to disperse, and adjust the pH of the liquid to 7.55 with 5.6 ml of sodium dihydrogen phosphate solution (0.5 mol / l). With water for injection, the above-mentioned liquid medicine is settled to 1000ml, and the pH value of retesting is 7.61. Filter and fill.

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Abstract

The invention discloses a tetradecyl sodium sulfate injection and a preparation method thereof. Sodium tetradecyl sulfate injection of the present invention, its raw material formula comprises following components: disodium hydrogen phosphate, sodium tetradecyl sulfate, benzyl alcohol, water and pH adjusting agent; Said sodium tetradecyl sulfate injection The pH of the liquid=7.5~7.9. The preparation method of sodium tetradecyl sulfate injection of the present invention comprises the following steps: mixing the aqueous solution of disodium hydrogen phosphate with pH=8.4 to 8.8 and the mixed solution of benzyl alcohol with the tetradecyl sodium Alkyl sodium sulfate is mixed evenly, and the pH regulator is added to make the pH of the mixed system to 7.5-7.9. The sodium tetradecyl sulfate injection of the invention has good stability, high content of active ingredients, meets the requirements of pharmacopoeia standards, and has the potential of clinical application.

Description

technical field [0001] The invention relates to a sodium tetradecyl sulfate injection and a preparation method thereof. Background technique [0002] Varicose veins refer to tortuous and dilated veins due to factors such as blood stasis and weak venous walls. The most common site of varicose veins is the lower extremities. As the most important disease of the venous system, varicose veins of the lower extremities have remained high, and the domestic incidence rate is as high as 9.6%. According to literature reports, the incidence rate in countries such as Italy, France, Spain and South Wales has reached 30%, and on average, one person in every three people suffers from varicose veins of the lower extremities. [0003] The treatment of varicose veins of the lower extremities used to be mainly through surgical extraction, but with the improvement of people's quality of life, surgical extraction has gradually been eliminated, and drug treatment has become the mainstream. In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/255A61K47/04A61K47/08A61P9/14
Inventor 黄臻辉陈辰狄颖峰张志刚丁金国
Owner SPH NO 1 BIOCHEM & PHARMA CO LTD
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