Medicine composition for treating primary alveolar hydatid disease as well as preparation method and application thereof

A technology of alveolar echinococcosis and composition, applied in the field of medicine, capable of solving problems such as interruption of treatment

Inactive Publication Date: 2015-08-19
段占娥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still failed cases reported, mainly due to the severe side effects of this class of drugs such as liver toxicity, which lead to the interruption of treatm

Method used

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  • Medicine composition for treating primary alveolar hydatid disease as well as preparation method and application thereof
  • Medicine composition for treating primary alveolar hydatid disease as well as preparation method and application thereof
  • Medicine composition for treating primary alveolar hydatid disease as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0018] (1) Weigh 1.2kg of Altairum chinensis and 1.2kg of Shijunzi, combine them, crush them, and extract 3 times with an ethanol solution with a volume fraction of 95%. Refluxing extraction with an ethanol solution about 10 times the total amount of secondary medicinal materials for 1.5 hours, filtering through four layers of gauze, and combining the ethanol extract;

[0019] (2) Weigh 0.3kg Daphne genkwa, 0.9kg cassia twig, 0.9kg green bark, 1.2kg black plum, 0.9kg Atractylodes macrocephala, and 1.1kg Trichosanthes bark, combine, crush, decoct twice with water, and add the total amount of medicinal materials for the first time About 10 times of purified water, decoct for 1.5 hours, add purified water of about 8 times the total amount of medicinal materials for the second time, decoct for 1 hour, and combine the decoction;

[0020] (3) Concentrate the decoction in step (2) under reduced pressure at...

Embodiment 2

[0021] Example 2: Effect test of traditional Chinese medicine dry ointment powder on rats with primary alveolar echinococcosis

[0022] Kunming female mice, weighing 18-22g. Twelve mice were randomly selected as the blank control group, and the remaining mice were intragastrically administered 100 mL alveolar Echinococcus eggs (storage concentration: 2000 eggs / 1 mL PBS) to establish a primary alveolar echinococcosis infection model. The model mice were randomly divided into drug treatment group and model control group, 12 in each group. The primary alveolar coccus infection mouse model was given 2 months after the establishment of the drug, and the test drug dosage standard was as follows: taking the body weight of the mice as a benchmark, intragastric administration of 618.2 mg / kg of Chinese medicine dry cream powder prepared in Example 1, 1 time / d, continuous treatment for 35 days. Both the model control group and the blank control group were given the same volume of disti...

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Abstract

The invention discloses a medicine composition for treating primary alveolar hydatid disease as well as a preparation method and application thereof. The medicine composition is prepared from the following raw traditional Chinese medicines in parts by weight: 9-17 parts of pharbitis seed, 9-17 parts of quisqualis indica, 2-3 parts of daphne genkwa, 7-11 parts of cassia twig, 7-11 parts of green tangerine peel, 10-15 parts of smoked plum, 7-11 parts of bighead atractylodes rhizome and 9-12 parts of snakegourd peel. The preparation method comprises the following steps: selecting pharbitis seed and quisqualis indica, and performing reflux extraction on pharbitis seed and quisqualis indica by using ethanol solutions; adding water into surplus medicinal materials to be decocted and extracted; mixing with ethanol extract liquid and standing; condensing filter liquid and drying. The obtained extract has a prominent treatment effect on primary alveolar hydatid disease of mice.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating primary alveolar echinococcosis, a preparation method and application thereof. Background technique [0002] Alveolar echinococcosis is a potentially fatal zoonotic disease caused by infection with alveolar echinococcosis. At present, benzimidazoles such as mebendazole and albendazole are used clinically to treat alveolar echinococcosis. This type of drug successfully inhibits the growth and recurrence of alveolar echinococcosis in some patients, prolongs their life span and The postoperative quality of life was significantly improved. According to reports, the clinical treatment success rate of benzimidazoles ranges from about 55% to 90% (Hemphill A, Spicher M, Stadelmann B, et al. Innovative chemotherapeutic treatment options for alveolar and cystic echinococcosis[J]. Parasitology, 2007 , 34(12):1657-1670.). However, t...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P33/10
Inventor 段占娥
Owner 段占娥
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