A device and method for producing medical tissue engineering scaffolds

Abstract

The invention disclose a device and method for producing a medical tissue engineering scaffold, wherein the device mainly comprises a fuse extrusion system, an electro spinning membrane loading and collecting system, a three-dimensional motion platform system, a process controlling system and a support frame; the fuse extrusion system comprises a servo motor, a cylinder, a feed inlet, a screw, a shaft coupler, a heater and an insulation cover; the electro spinning membrane loading and collecting system comprises a membrane loading roller, a transitional roller, a membrane collecting roller and a roller driving motor; the three-dimensional motion platform system comprises a base plate, an X-direction motion mechanism, a Y-direction motion mechanism and a Z-direction motion mechanism; a three-dimensional digital model of a product is converted into 3D (three dimensional) print command through data conversion and the controlling system, and a tissue engineering scaffold product is finally printed. According to the device and the method, provided by the invention, macroscopic and microcosmic lacuna bioengineered tissue scaffolds are formed by adopting fuse grids and electro spinning membranes in a multi-layer composite manner, and the membranes and the grids are bonded together through fuses, and the clearances of the fuses are adjustable, and the clearances which are laid by the electro spinning membranes can reach the micron order.

Description

technical field [0001] The present invention relates to the fields of additive manufacturing and biological tissue culture, in particular to a 3D printer for the preparation of biological tissue engineering scaffolds, which combines fusion deposition forming and sheet lamination forming technology to prepare tissue engineering that is more conducive to cell culture Porous scaffold. Background technique [0002] 3D printing technology (also known as additive manufacturing technology) has set off a new wave of development at home and abroad. With the continuous maturity of technology, 3D printing is increasingly used in manufacturing, medical, cultural and creative, aerospace and other industries. Among them, the preparation of biological tissue engineering scaffolds by 3D printing has become a research hotspot in the medical field. Tissue engineering scaffolds transport nutrients and excrete metabolites for cell growth, provide carriers for cell growth, and are widely used i...

AI Technical Summary

Problems solved by technology

Common preparation methods for tissue engineering scaffolds include phase separation / freeze-drying, solvent casting / particle leaching, chemical foaming, etc. Problems such as the use of toxic solvents cannot be avoided in the process

[0003] The method of preparing tissue engineering scaffolds by 3D printing technology is a hotspot in the field of tissue engineering research. It has the characteristics of high precision and good surface quality of the molded products, but it is difficult to meet the requirements in terms of micron-scale scaffold pore size.

Images