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Copper metal complex and compound prepared from copper metal complex and human serum albumin as well as synthesis method and application thereof

A technology of human serum albumin and its synthesis method, which is applied in the field of copper metal complexes and their complexes with human serum albumin, to achieve significant in vitro anti-tumor activity and good medicinal value

Inactive Publication Date: 2015-08-19
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no public report on the synthesis and pharmacological activity of copper (II) metal complexes with phenyl-2-pyridylketal 4,4'-dimethyl-3-thiosemicarbazide as ligands

Method used

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  • Copper metal complex and compound prepared from copper metal complex and human serum albumin as well as synthesis method and application thereof
  • Copper metal complex and compound prepared from copper metal complex and human serum albumin as well as synthesis method and application thereof
  • Copper metal complex and compound prepared from copper metal complex and human serum albumin as well as synthesis method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the synthesis of Cu(Bp44mT)Cl complex

[0034] The synthetic route is as follows:

[0035]

[0036] The specific synthesis method is:

[0037]1) Dissolve 10mmol of phenyl-2-pyridyl ketone (1832.1mg) in 20ml of ethanol (the concentration of solvent ethanol is 50v / v%), stir at 50°C for 15min to obtain a solution, and dissolve the above solution one by one Add dropwise to 20ml of ethanol solution (concentration of solvent ethanol: 60v / v%) added with 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg), reflux and stir at 50°C for 24h to obtain light yellow For the precipitate, filter the light yellow precipitate obtained above, wash with absolute ethanol and ether three times, and dry to obtain the ligand phenyl-2-pyridyl ketal 4,4'-dimethyl-3-amino Thiourea;

[0038] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of methanol (the concentration of solvent methanol is 60v / v%) solution, dropwise added to the solution containing 1mmol of phenyl-2-py...

Embodiment 2

[0051] Embodiment 2: the synthesis of Cu(Bp44mT)Cl complex

[0052] 1) Dissolve 10mmol of phenyl-2-pyridyl ketone (1832.1mg) in 20ml of methanol (the concentration of solvent methanol is 80v / v%), stir at 60°C for 15min to obtain a solution, and dissolve the above solution one by one Add dropwise to 20ml of 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg) in methanol (concentration of solvent methanol: 20v / v%) solution, reflux and stir at 50°C for 24h to obtain light yellow For the precipitate, filter the light yellow precipitate obtained above, wash with absolute ethanol and ether three times, and dry to obtain the ligand phenyl-2-pyridyl ketal 4,4'-dimethyl-3-amino Thiourea;

[0053] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of methanol (the concentration of solvent methanol is 40v / v%) solution, dropwise added to the solution containing 1mmol phenyl-2-pyridyl ketal 4,4'-dimethyl-3-amino In 20ml of methanol (the concentration of solvent methanol is 30v / v%) so...

Embodiment 3

[0055] Embodiment 3: the synthesis of Cu(Bp44mT)Cl complex

[0056] 1) Dissolve 10mmol of phenyl-2-pyridyl ketone (1832.1mg) in 20ml of ethanol (the concentration of solvent ethanol is 40v / v%), stir at 30°C for 20min to obtain a solution, and dissolve the above solution one by one Add 10mmol 4,4'-dimethyl-3-thiosemicarbazide (1191.9mg) dropwise into 20ml of ethanol (concentration of solvent ethanol: 70v / v%) solution, stir and react at 35°C for 72h to obtain light Yellow precipitate, the light yellow precipitate obtained above was filtered, washed with water three times, and dried to obtain the ligand phenyl-2-pyridyl ketal 4,4'-dimethyl-3-thiosemicarbazide;

[0057] 2) will contain CuCl 2 2H 2 O (170.48mg, 1mmol) 20ml of ethanol (the concentration of solvent ethanol is 80v / v%) solution, dropwise added to the solution containing 1mmol of phenyl-2-pyridyl ketal 4,4'-dimethyl-3-amino In 20ml of ethanol (the concentration of solvent ethanol is 50v / v%) solution of thiourea ligan...

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Abstract

The invention discloses a copper metal complex and a compound prepared from the copper metal complex and human serum albumin as well as a synthesis method and application thereof. The synthesis method of the copper metal complex comprises the following steps: taking phenyl-2-pyridyl ketone and 4,4'-dimethyl-3-thiosemicarbazide, taking an alcohol material as a solvent, reacting, generating precipitate, collecting the precipitate and washing the precipitate to obtain a ligand; taking the ligand which is phenyl-2-pyridyl ketone and contracting 4,4'-dimethyl-3-thiosemicarbazide and CuC12.2H2O, taking the alcohol material as the solvent, reacting, enabling a reactant to stand, crystallizing and collecting crystals to prepare the copper metal complex. The compound is prepared by incubating the copper metal complex and human serum albumin through a solution process. The structure of the copper metal complex is as shown in the following formula (I) which is as shown in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a copper metal complex and its complex with human serum albumin, as well as their synthesis method and application. Background technique [0002] Cancer (mainly referring to malignant tumors) is one of the most serious diseases that endanger human health. The most common and serious malignant tumors in my country mainly include: breast cancer, cervical cancer, lymphoma, leukemia, lung cancer, liver cancer and other types (Farrell N , et al. Cancer Res., 1992), and antineoplastic drugs are gradually developed along with the great threat of cancer to human health. After decades of research and development by scientific researchers, different types of anti-tumor drugs with different efficacy characteristics and different mechanisms of action have been launched and applied in clinical treatment and adjuvant therapy. Among them, in 1965, Rosenberg et al. found that cisplatin had sign...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61K31/555C07K14/765A61K38/38A61K47/42A61P35/00
CPCC07F1/08A61K38/385A61K47/42C07K14/765
Inventor 杨峰梁宏齐金旭
Owner GUANGXI NORMAL UNIV
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