Application of traditional Chinese medicine composition serving as preparation for treating dental ulcer
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A technology for oral ulcers and compositions, which is applied in the application field of traditional Chinese medicine compositions as preparations for the treatment of oral ulcers, and can solve the problems of undisclosed traditional Chinese medicine compositions and the inability to obtain treatment of oral ulcers, etc.
Active Publication Date: 2015-08-26
博济医药科技股份有限公司
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[0011] CN101940630A discloses a traditional Chinese medicine composition for treating gingivitis and a preparation method thereof, but the document does not disclose th
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[0019] The technical solution of the present invention will be further described below in combination with experiments.
[0020] 1. Materials
[0021] 1.1 Animals
[0022] SPF grade SD rats, male, 180-220g, provided by Zhejiang Experimental Animal Center, certificate number: SCXK (Zhejiang) 2014-0001; common grade guinea pigs, male, 250-300g, provided by Qinglong Mountain Animals, Jiangning District, Nanjing Provided by the breeding farm, certificate number: SCXK (Su) 20120008. The experimental animals were kept in an animal room at 22±2°C, free to eat and drink, and a 12h light / dark cycle was adopted indoors.
[0023] 1.2 Drugs and instruments
[0024]Ice lotus buccal tablets, ice lotus buccal tablets blank excipients, dissolved in double distilled water and set the experimental dose (smear administration, the dose is 50, 100, 200mg / kg three doses, respectively 1,2 of the daily dose of normal clinical administration. , and 4 times, or 5, 10 and 20 times of the clinical do...
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Abstract
The invention discloses application of a traditional Chinese medicine composition serving as a preparation for treating dental ulcer. An animal experiment proves that the traditional Chinese medicine composition disclosed by the patient CN101940630A can effectively reduce big guinea pig dental ulcer degree caused by phenol simulation or fulguration and model rats and the hydroxyproline content of guinea pig buccal membrane tissues and promote ulcer healing, the medicine effect is slightly higher than that of the same dosage of mirabilitum praeparatum preparation. Pathological tissue checking further proves that the positive effects of inhibiting inflammatory cell infiltration and keeping the completeness of the epithelial tissue structure are achieved, and dental ulcer can be effectively treated.
Description
technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition as a preparation for treating oral ulcers. Background technique [0002] Oral diseases are relatively common diseases, because people's unhealthy diet or bad living habits can cause oral diseases. Common oral ulcers, periodontal disease, pulp disease, wear, juvenile periodontitis, tongue disease, lip disease, dental caries, tetracycline teeth, simple periodontitis, oral candidiasis, etc. are common oral diseases, The incidence of these common oral diseases is very high, but they are often overlooked by people. [0003] Oral ulcers are the most common recurrent oral mucosal ulcerative lesions, mostly on the lips, cheeks, vestibular groove, tongue tip, tongue side edge, etc., with single or multiple pale yellow or off-white ulcerated spots, accompanied by pain or Pain when stimulated. T...
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