A kind of gold nano material and its preparation method and application

A gold nanometer and gold nanorod technology, applied in the field of nanomaterial preparation, can solve problems such as affecting the wavelength of surface plasmon resonance, and achieve the effect of a simple preparation method

Active Publication Date: 2017-06-06
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, gold nanorods are easy to aggregate in vivo, which affects the surface plasmon resonance wavelength.

Method used

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  • A kind of gold nano material and its preparation method and application
  • A kind of gold nano material and its preparation method and application
  • A kind of gold nano material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1, the preparation of gold nanomaterial

[0073] 1. Preparation of gold nanorods (AuNRs)

[0074] 1. Gold seed preparation: 1.5ml of 0.01M cetyltrimethylammonium bromide (CTAB) and 50μl of 0.01M Au 3+ Mix and quickly add 120 μl of 0.01M NaBH 4 , shake, and place in a water bath at 28°C for 2-3 hours to obtain gold species.

[0075] 2. Preparation of AuNRs: Add 4ml of 0.01M Au to 80ml of 0.1M CTAB 3+ , under shaking, add AgNO 3 solution (0.01 M, 1 ml). Add 0.8ml of vitamin C (Vc, 0.01M) under shaking, after the color becomes colorless, shake for 1-2min, add 1ml of hydrochloric acid (HCl, 0.01M), adjust the pH value to 6-7, and finally add 200μl of Gold species (0.01M concentration). After reacting at 28°C for 24h, the obtained wine red solution was centrifuged at 10,000rpm for 10min, centrifuged twice, washed with deionized water, and excess CTAB was removed to obtain AuNRs with a length of 60-80nm, such as figure 1 (a) shows the TEM image of AuNRs.

...

Embodiment 2

[0084] Embodiment 2, the application of gold nanomaterial

[0085] 1. Using the AuNRs@MSN@Lipid and AuNRs@MSN two kinds of nanoparticles prepared by the method in Example 1 of the present invention, the same amount of the above two kinds of nanoparticles was added to breast cancer cells (MCF-7) for cultivation, and determined In different time (0 ~ 9h, specifically can be 1h, 3h, 6h, 9h) the content of nanoparticles phagocytized by cells, the results are as follows image 3 Shown is the change of the content of gold element inside the cells with time after the cells phagocytized the nanoparticles at different times. Depend on image 3 It can be seen that by comparing the content of gold elements in the cells in different time periods, it is proved that the liposome layer is helpful for the endocytosis of the cells.

[0086] 2. Disperse the AuNRs@MSN@Lipid nanoparticles prepared by the method in Example 1 of the present invention into an aqueous solution and configure them at...

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Abstract

The invention discloses a gold nano-material as well as a preparation method and application thereof. The gold nano-material consists of gold nano-rods, mesoporous silica coated on the gold nano-rods, and liposomes adsorbed on the surface of mesoporous silica. The preparation method of the gold nano-material comprises the following steps: (1) coating mesoporous silica on the gold nano-rods to obtain the mesoporous silica coated gold nano-rods; and (2) mixing the mesoporous silica coated gold nano-rods with a liposome solution, and performing adsorption to obtain the gold nano-material. The gold nano-material disclosed by the invention can be used for preparing medicines or medicine carriers for treating tumors, and the medicines consist of the gold nano-material and auxiliary materials; the gold nano-material is coated with the liposomes which can be rapidly accumulated in cancer cells, ensures that functional molecules can be loaded outside nano-particles or different biological medicines or macromolecules can be loaded inside the nano-particles, and can be used for preparing the medicines for treating tumors; and the gold nano-material can be preserved for a long time.

Description

technical field [0001] The invention relates to a gold nano material and its preparation method and application, belonging to the field of nano material preparation. Background technique [0002] Gold nanorods are rod-shaped gold nanoparticles with a size ranging from a few nanometers to hundreds of nanometers. Because the surface plasmon resonance wavelength (550nm-1550nm) of gold nanorods changes with the aspect ratio of gold nanorods, it has a very high surface electric field intensity enhancement effect and adjustable photothermal conversion efficiency. Due to their unique optical, photoelectric, photothermal and biological properties, gold nanorods have received great attention in photothermal therapy. However, gold nanorods are easy to aggregate in vivo, which affects the surface plasmon resonance wavelength. [0003] According to the regulations of the International Union of Pure and Applied Chemistry (IUPAC), mesoporous materials refer to a class of porous material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K41/00A61K31/337A61K31/704A61P35/00
Inventor 李峻柏秦晨晨费进波王安河
Owner INST OF CHEM CHINESE ACAD OF SCI
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