O/W nano-emulsion and low-energy-consumption preparation method thereof

A technology of nanoemulsion and liquid paraffin, applied in mixing methods, chemical instruments and methods, dissolution, etc., can solve problems such as heat loss, expensive equipment, high energy, etc., and achieve small particle size, narrow distribution, and good stability Effect

Inactive Publication Date: 2015-09-02
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of preparing nanoemulsions by high-energy emulsification is that relatively expensive equipment is required and a large amount of energy is consumed
In addition, heat loss is also prone to occur during the emulsification process

Method used

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  • O/W nano-emulsion and low-energy-consumption preparation method thereof
  • O/W nano-emulsion and low-energy-consumption preparation method thereof
  • O/W nano-emulsion and low-energy-consumption preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] In 100 parts by weight, get 3 parts of nonionic surfactant lauryl polytetraoxyethylene ether, 7 parts of liquid paraffin, be placed in reactor, stir 5min with 600rpm speed on magnetic stirrer, at this stirring speed Add pure water drop by drop, the dropping rate is controlled at 0.1mL / min, add 90 parts of pure water and pour the prepared nanoemulsion into a straight cylinder bottle for later use. The experimental temperatures were 15°C, 20°C, 25°C, 35°C, 45°C, and 55°C, respectively.

[0022] Investigate the particle diameter of the prepared nanoemulsion as follows:

[0023] The particle size distribution of the nanoemulsion was determined with (ZEN3690, Malvern Instrument Ltd). The laser particle size nanometer instrument uses a He-Ne laser light source with a wavelength of 632.8nm. During the test, the scattering angle is 90°, the accumulation time is 240-300s, the scanning is repeated for more than 3 times, and the measurement temperature is 25°C. Dilute the emulsi...

Embodiment 2

[0025] At 25°C, in terms of 100 parts by weight, take 3 parts of nonionic surfactant lauryl polytetraoxyethylene ether, 7 parts of liquid paraffin, put them in the reactor and stir on a magnetic stirrer for 5 minutes, and control the stirring rate respectively 100rpm, 200rpm, 300rpm, 400rpm, 500rpm, 600rpm, 700rpm, and add pure water drop by drop at this stirring rate, the dropping speed is controlled at 0.1mL / min, add 90 parts of pure water, pour the prepared nanoemulsion Put it in a straight bottle for later use.

[0026] Detect by the method described in embodiment one, its result is as follows figure 2 and 3 as shown, figure 2 It shows that the particle size of the prepared nanoemulsion is larger at a low stirring rate of 100rpm, and the particle size of the prepared nanoemulsion is basically the same at a stirring rate of 200rpm-700rpm. image 3 It shows that in the case of stirring rate of 100rpm, the prepared emulsion contains a part of nanoemulsion droplets of abo...

Embodiment 3

[0028] At 25°C, control the ratio of nonionic surfactant and oil phase to 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 3:7, 2:8, Stir 5min with 600rpm speed on the magnetic stirrer, dropwise add pure water (water content is respectively 70wt%, 80wt%, 90wt%) under this stirring speed, drop rate is controlled at 0.1mL / min, the nanoemulsion that makes Pour the liquid into a straight bottle for later use.

[0029] Detect by the method described in embodiment one, its result is as follows Figure 4 as shown, Figure 4 It shows that with the increase of the surfactant content, the particle size first decreases and then increases, and the water content has little effect on the particle size.

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Abstract

The invention discloses O/W nano-emulsion and a low-energy-consumption preparation method thereof. The O/W nano-emulsion comprises the following components: 2-27 parts of an oil phase, 1-18 parts of a nonionic surfactant and the balance being water. The O/W nano-emulsion is small in particle diameter, narrow in distribution, good in stability and free of layering phenomenon after being placed for three months. According to the method, the O/W nano-emulsion with the different particle diameters can be prepared by adjusting and controlling experiment conditions, and the nano-emulsion with the proper particle diameters can not damage healthy skin and cells.

Description

technical field [0001] The invention relates to a nanoemulsion and a preparation method thereof, belonging to the technical field of nanoemulsion preparation. Background technique [0002] Nanoemulsions are between microemulsions and ordinary emulsions, also known as microemulsions or microemulsions, and the particle size of the dispersed phase droplet particles is generally 20-200nm. From a thermodynamic point of view, a nanoemulsion is an unstable system, but it has long-term kinetic stability due to its small particle size and narrow distribution range. Compared with ordinary emulsions, nanoemulsions have a larger specific surface area and free energy, which makes this type of emulsion an effective delivery system and is widely used in medicine, cosmetics and other fields. [0003] The traditional preparation method of nanoemulsion is high energy emulsification method. A large amount of energy is provided by means of micro-fluid jetting, high-pressure homogenization or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/08
Inventor 张晓红许红岩冯伟郭荣
Owner YANGZHOU UNIV
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