Plant-based semi-interpenetrating network haemostatic dressing and preparation method thereof

The technology of semi-interpenetrating network and hemostatic dressing is applied in the field of semi-1 type interpenetrating network structure medical hemostatic dressing. , good biocompatibility, the effect of improving the liquid absorption rate

Active Publication Date: 2015-09-16
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently commercially available plant polysaccharide medical hemostatic dressings are generally made of single-component plant polysaccharides through chemical cross-linking polymerization, which has poor biocompatibility and chemical cross-linking agents are easy to remain; Spongy dressings prepared by doping and mixing have disadvantages such as poor strength, less liquid absorption, and slow expansion, which affect or limit the use of such dressings in internal and external wounds

Method used

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  • Plant-based semi-interpenetrating network haemostatic dressing and preparation method thereof
  • Plant-based semi-interpenetrating network haemostatic dressing and preparation method thereof
  • Plant-based semi-interpenetrating network haemostatic dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 Preparation of plant-based sponge dressing

[0024] Accurately weigh 5.0g of cornstarch, put it into a 50ml beaker, add 30ml of twice distilled water (w / v, the starch to water ratio is 1g / 6ml), put it in a water bath at 80°C, and mechanically stir it for 30min to dissolve and fully gelatinize it. Set to defoam, called A solution. After casting, it was vacuum-dried at room temperature for 2 hours to form a film, which is called A film. After He plasma treatment, the He flow rate was controlled to be 510L / min, the distance between the film and the electrode was 8mm, the processing power was 60W, and the discharge frequency was 10kHz. After being treated with He plasma for 10 min, the A film was exposed to the air for 15 min, and then put into a 5% F68 aqueous solution. The grafting reaction was carried out in an ice-water bath at 4°C under nitrogen and oxygen exhaust conditions. The grafted A film was called cornstarch-F68 film, and was washed with flowing dist...

Embodiment 2

[0028] Example 2 Preparation of Plant-Based Powdered Dressing

[0029]Accurately weigh 10.0 g of pregelatinized potato starch, put it into a 50 ml beaker, stir it magnetically for 10 min to fully dissolve it, and call it A liquid. After casting, it was vacuum-dried at room temperature for 2 hours to form a film, called A film, treated with Ar plasma, the Ar flow rate was controlled at 500L / min, the distance between the film and the electrode was 7mm, the processing power was 60W, and the discharge frequency was 10kHz. After being treated with Ar plasma for 15 minutes, the A film was exposed to the air for 15 minutes, and then put into a solution containing 10% by mass of P338. The graft polymerization was carried out in an ice-water bath at 4°C under nitrogen and oxygen exhaust conditions. The grafted A film was called pregelatinized potato starch-P338 film. Rinse with flowing distilled water for 24h to remove unreacted P338 and the resulting copolymer. The obtained pregelat...

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Abstract

The invention discloses a plant-based semi-interpenetrating network haemostatic dressing, which is a medical dressing with a semi-I type interpenetrating network (Semi-I) structure employing plant polysaccharide as matrix. Due to the unique semi-I type interpenetrating network structure, the performance indexes of the plant-based semi-interpenetrating network haemostatic dressing in the aspects of liquid absorbency rate, liquid-absorbing saturation time and expanding volume are obviously improved; and the plant-based semi-interpenetrating network haemostatic dressing is easy to bond and adhere, absorbable after an operation, and suitable for immediate stopping of bleeding in various surgical operations.

Description

technical field [0001] The invention relates to a medical dressing for medical equipment, which is suitable for immediate hemostasis in various surgical operations. The plant-based semi-interpenetrating network hemostatic dressing is specifically a medical hemostatic dressing with a semi-1 type interpenetrating network (Semi-I) structure as a matrix of plant polysaccharide-starch. Background technique [0002] Plant polysaccharides are compounds composed of many identical or different monosaccharides with α- or β-glycosidic bonds that commonly exist in the natural plant kingdom. Their unique molecular structure and physical and chemical properties make them display a variety of important functions in the body. Physiological functions, such as water absorption and moisturizing, lubrication and repair, etc. The currently commercially available plant polysaccharide medical hemostatic dressings are generally made of single-component plant polysaccharides through chemical cross-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/62A61L15/64C08J3/24
Inventor 王晓晨郈秀菊
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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