il-17a conjugates and uses thereof

A technology of IL-17A and conjugates, applied in the application, drug combination, fusion polypeptide and other directions, can solve the problems of pathological development and deterioration of interleukin-17A, and achieve the effect of high affinity and long half-life
CN104936981BActive Publication Date: 2018-02-27SHANGHAI HENGRUI PHARM CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI HENGRUI PHARM CO LTD
Publication Date
2018-02-27

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Abstract

Provided is an antibody that specifically recognizes IL-17A and can bind to IL-17A. It can be used to treat inflammatory and autoimmune diseases caused by high expression of interleukin-17A, including psoriasis, psoriatic arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory arthritis, etc.
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Description

technical field

[0001] The present invention relates to an IL-17A conjugate and its use as a therapeutic agent, especially as a therapeutic agent for various inflammatory or autoimmune diseases. Background technique

[0002] The cytokines of the interleukin-17 family are named interleukin-17A to interleukin-17F, respectively. At the same time, people also found their receptor family: interleukin-17 receptor A to interleukin-17 receptor E. These interleukin-17 cytokines can bind to corresponding receptor members to mediate different inflammatory responses.

[0003] The most representative member of this family is interleukin-17A. Lymphocytes that migrate to infected or injured sites in the body secrete interleukin-17A. On the one hand, interleukin-17A can induce the expression of inflammatory factors and chemokines, thereby recruiting more immune cells to reach the inflammatory site and aggravate the inflammatory response; on the other hand, interleukin-17A can also induce...

Claims

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